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W. K. Poole
Researcher at Brigham and Women's Hospital
Publications - 8
Citations - 3783
W. K. Poole is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Myocardial infarction & Digoxin. The author has an hindex of 7, co-authored 8 publications receiving 3593 citations.
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Journal ArticleDOI
Circadian variation in the frequency of onset of acute myocardial infarction
James E. Muller,Peter Stone,Zoltan G. Turi,John D. Rutherford,Charles A. Czeisler,Corette B. Parker,W. K. Poole,Eugene R. Passamani,Robert Roberts,Thomas L. Robertson +9 more
TL;DR: If coronary arteries become vulnerable to occlusion when the intima covering an atherosclerotic plaque is disrupted, the circadian timing of myocardial infarction may result from a variation in the tendency to thrombosis.
Journal ArticleDOI
TIMI Frame Count A Quantitative Method of Assessing Coronary Artery Flow
Gibson Cm,Christopher P. Cannon,Daley Wl,Dodge Jt,Brian M. Alexander,Susan J. Marble,Carolyn H. McCabe,Raymond L,Terry Fortin,W. K. Poole,Eugene Braunwald +10 more
TL;DR: The CTFC is a simple, reproducible, objective and quantitative index of coronary flow that allows standardization of TIMI flow grades and facilitates comparisons of angiographic end points between trials.
Journal ArticleDOI
Digoxin therapy and mortality after myocardial infarction. Experience in the MILIS Study.
James E. Muller,Zoltan G. Turi,Peter Stone,Robert E. Rude,Daniel S. Raabe,Allan S. Jaffe,Herman K. Gold,Nancy Gustafson,W. K. Poole,Eugene R. Passamani,Thomas W. Smith,Eugene Braunwald +11 more
TL;DR: The findings in the MILIS population do not support the assertion that digoxin therapy is excessively hazardous after infarction, but the existence of an undetected harmful effect can only be excluded with a randomized study.
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Pericarditis in acute myocardial infarction: characterization and clinical significance.
Geoffrey H. Tofler,James E. Muller,Peter Stone,Stefan N. Willich,Vicki G. Davis,W. K. Poole,T Robertson,Eugene Braunwald +7 more
TL;DR: To determine the significance of pericarditis following acute myocardial infarction, the hospital course and 12-month follow-up were analyzed in 703 patients enrolled in the Multicenter Investigation of the Limitation of Infarct Size (MILIS).
Journal ArticleDOI
Abrupt withdrawal of beta-blockade therapy in patients with myocardial infarction: effects on infarct size, left ventricular function, and hospital course.
C H Croft,Robert E. Rude,N Gustafson,Peter Stone,W. K. Poole,Robert Roberts,H W Strauss,Daniel S. Raabe,Lewis J Thomas,Allan S. Jaffe +9 more
TL;DR: Data indicate that the beta-blockade withdrawal phenomenon is not a major clinical problem in patients with acute myocardial infarction and beta-Blockade therapy can be discontinued abruptly during acute my Cardiac Infarction if clinically indicated.