B
Brian M. Alexander
Researcher at Foundation Medicine
Publications - 275
Citations - 13384
Brian M. Alexander is an academic researcher from Foundation Medicine. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 50, co-authored 264 publications receiving 9200 citations. Previous affiliations of Brian M. Alexander include Harvard University & University of Michigan.
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Journal ArticleDOI
TIMI Frame Count A Quantitative Method of Assessing Coronary Artery Flow
Gibson Cm,Christopher P. Cannon,Daley Wl,Dodge Jt,Brian M. Alexander,Susan J. Marble,Carolyn H. McCabe,Raymond L,Terry Fortin,W. K. Poole,Eugene Braunwald +10 more
TL;DR: The CTFC is a simple, reproducible, objective and quantitative index of coronary flow that allows standardization of TIMI flow grades and facilitates comparisons of angiographic end points between trials.
Journal ArticleDOI
Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA)
Paul W. Sperduto,T. Jonathan Yang,Kathryn Beal,Hubert Y. Pan,Paul D. Brown,Ananta S Bangdiwala,Ryan Shanley,Norman Yeh,Laurie E. Gaspar,Steve Braunstein,Penny K. Sneed,John M Boyle,John P. Kirkpatrick,Kimberley S. Mak,Helen A. Shih,Alex Engelman,David Roberge,Nils D. Arvold,Brian M. Alexander,Mark M. Awad,Joseph N. Contessa,Veronica Chiang,J.G. Hardie,Daniel J. Ma,Emil Lou,William Sperduto,Minesh P. Mehta +26 more
TL;DR: The updated Lung-molGPA incorporating gene alteration data into the DS-GPA is a user-friendly tool that may facilitate clinical decision making and appropriate stratification of future clinical trials.
Journal ArticleDOI
Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials
Benjamin M. Ellingson,Martin Bendszus,Martin Bendszus,Jerrold L. Boxerman,Daniel P. Barboriak,Bradley J. Erickson,Marion Smits,Marion Smits,Sarah J. Nelson,Elizabeth R. Gerstner,Elizabeth R. Gerstner,Brian M. Alexander,Gregory V. Goldmacher,Wolfgang Wick,Wolfgang Wick,Michael A. Vogelbaum,Michael A. Vogelbaum,Michael Weller,Evanthia Galanis,Jayashree Kalpathy-Cramer,Lalitha K. Shankar,Paula M. Jacobs,Whitney B. Pope,Dewen Yang,Caroline Chung,Michael V. Knopp,Soonme Cha,Martin J. van den Bent,Martin J. van den Bent,Susan M. Chang,W. K. Alfred Yung,Timothy F. Cloughesy,Patrick Y. Wen,Mark R. Gilbert,Mark R. Gilbert,Andrew Whitney,David Sandak,Al Musella,Chas Haynes,Max Wallace,David Arons,Ann E Kingston +41 more
TL;DR: The current document outlines consensus recommendations for a standardized Brain Tumor Imaging Protocol (BTIP), along with the scientific and practical justifications for these recommendations, resulting from a series of discussions between various experts involved in aspects of neuro-oncology neuroimaging for clinical trials.
Journal ArticleDOI
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Patrick Y. Wen,Michael Weller,Eudocia Q. Lee,Brian M. Alexander,Jill S. Barnholtz-Sloan,Floris P. Barthel,Tracy T. Batchelor,Ranjit S. Bindra,Susan M. Chang,E. Antonio Chiocca,Timothy F. Cloughesy,John DeGroot,Evanthia Galanis,Mark R. Gilbert,Monika E. Hegi,Craig Horbinski,Raymond Y. Huang,Andrew B. Lassman,Emilie Le Rhun,Michael Lim,Minesh P. Mehta,Ingo K. Mellinghoff,Giuseppe Minniti,David Nathanson,Michael Platten,Matthias Preusser,Patrick Roth,Marc Sanson,David Schiff,Susan C Short,Martin J B Taphoorn,Joerg C. Tonn,Jonathan Tsang,Roel G.W. Verhaak,Andreas von Deimling,Wolfgang Wick,Gelareh Zadeh,David A. Reardon,Kenneth Aldape,Martin J. van den Bent +39 more
TL;DR: Novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies and viral therapies will be reviewed, as well as the current challenges and future directions for research.
Journal ArticleDOI
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.
Daniel N. Cagney,Allison Martin,Paul J. Catalano,Amanda J. Redig,Nan Lin,Eudocia Q. Lee,Patrick Y. Wen,Ian F. Dunn,Wenya Linda Bi,Stephanie E. Weiss,Daphne A. Haas-Kogan,Brian M. Alexander,Ayal A. Aizer +12 more
TL;DR: Generalizable estimates of the incidence and prognosis for patients with brain metastases at diagnosis of a systemic malignancy are provided to allow for appropriate utilization of brain-directed imaging as screening for subpopulations with cancer and have implications for clinical trial design and counseling of patients regarding prognosis.