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Wade V. Welshons
Researcher at University of Missouri
Publications - 99
Citations - 17891
Wade V. Welshons is an academic researcher from University of Missouri. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 51, co-authored 99 publications receiving 16524 citations. Previous affiliations of Wade V. Welshons include University of California, San Francisco & University of Wisconsin-Madison.
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Journal ArticleDOI
Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses
Laura N. Vandenberg,Theo Colborn,Tyrone B. Hayes,Jerrold J. Heindel,David R. Jacobs,Duk Hee Lee,Toshi Shioda,Ana M. Soto,Wade V. Welshons,R. Thomas Zoeller,John Peterson Myers +10 more
TL;DR: It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisphenol A at Levels of Human Exposure
TL;DR: Concern with human exposure to BPA derives from identification of molecular mechanisms mediating effects in human and animal tissues at very low doses, in vivo effects in experimental animals caused by low doses within the range of human exposure, and widespread human Exposure to levels of BPA that cause adverse effects in animals.
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Nuclear localization of unoccupied oestrogen receptors.
TL;DR: It is found that cytoplasts prepared from GH3 cells contain little oestrogen-binding activity and that most of the unfilled oestrogens receptors are associated with the nuclear fraction, suggesting that the standard model is in error and that the unoccupied receptor is nuclear in the intact cell.
Journal ArticleDOI
Large Effects from Small Exposures. I. Mechanisms for Endocrine-Disrupting Chemicals with Estrogenic Activity
Wade V. Welshons,Kristina A. Thayer,Barbara M. Judy,Julia A. Taylor,Edward M. Curran,Frederick S. vom Saal +5 more
TL;DR: Four fundamental issues are problematic for risk assessment methods used by regulatory agencies, because they challenge the traditional use of extrapolation from high-dose testing to predict responses at the much lower environmentally relevant doses.