W
Waka Kojima
Researcher at Institute of Medical Science
Publications - 6
Citations - 157
Waka Kojima is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Mitophagy & Autophagy. The author has an hindex of 3, co-authored 4 publications receiving 75 citations. Previous affiliations of Waka Kojima include University of Tokyo.
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Journal ArticleDOI
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
Koji Yamano,Reika Kikuchi,Waka Kojima,Waka Kojima,Ryota Hayashida,Ryota Hayashida,Fumika Koyano,Junko Kawawaki,Takuji Shoda,Yosuke Demizu,Mikihiko Naito,Keiji Tanaka,Noriyuki Matsuda +12 more
TL;DR: It is shown that in addition to binding ATG8 proteins, one of the critical autophagy adaptors, OPTN, possesses an ATG9A binding site that contributes to de novo synthesis of autophagosomal membranes.
Journal ArticleDOI
Parkinson’s disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
Noriyuki Matsuda,Noriyuki Matsuda,Mayumi Kimura,Bruno B. Queliconi,Waka Kojima,Waka Kojima,Masaki Mishima,Kenji Takagi,Fumika Koyano,Koji Yamano,Tsunehiro Mizushima,Yutaka Ito,Keiji Tanaka,Keiji Tanaka +13 more
TL;DR: It is inferred that a key to understanding the biological function of DJ-1 resides in its methylglyoxal-adduct hydrolase activity, which protects low-molecular thiols, including CoA, from aldehydes.
Journal ArticleDOI
Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1.
Waka Kojima,Waka Kojima,Yuki Kujuro,Yuki Kujuro,Kei Okatsu,Kei Okatsu,Queliconi Bruno,Fumika Koyano,Mayumi Kimura,Koji Yamano,Keiji Tanaka,Keiji Tanaka,Noriyuki Matsuda,Noriyuki Matsuda +13 more
TL;DR: The mitochondrial matrix localization of various pathogenic and artificial DJ‐1 mutants by multiple independent experimental approaches including cellular fractionation, proteinase K protection assays, and specific immunocytochemistry is shown.
Journal ArticleDOI
Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy
Waka Kojima,Waka Kojima,Koji Yamano,Hidetaka Kosako,Kenichiro Imai,Reika Kikuchi,Keiji Tanaka,Noriyuki Matsuda +7 more
TL;DR: Macroautophagy is an intracellular degradation process that delivers cytosolic materials and/or damaged organelles to lysosomes as mentioned in this paper.De novo synthesis of the autophagosome membrane occurs wit...
Journal ArticleDOI
Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method
Ryota Hayashida,Reika Kikuchi,Kenichiro Imai,Waka Kojima,Tetsuya Yamada,Miho Iijima,Hiromi Sesaki,Keiji Tanaka,Noriyuki Matsuda,Koji Tenri-shi Yamano +9 more
TL;DR: In this article , a method that detects intracellular interactions between E2s and Parkin was developed to identify multiple E2-E3 interactions with activated Parkin on damaged mitochondria during mitophagy.