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Walkyria O. Sampaio
Researcher at Universidade Federal de Minas Gerais
Publications - 23
Citations - 2501
Walkyria O. Sampaio is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Hemodynamics & Vasodilation. The author has an hindex of 14, co-authored 22 publications receiving 2140 citations. Previous affiliations of Walkyria O. Sampaio include Universidade Federal de Ouro Preto & University of Itaúna.
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Journal ArticleDOI
The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)
Robson A.S. Santos,Walkyria O. Sampaio,Andréia Carvalho Alzamora,Daisy Motta-Santos,Natalia Alenina,Michael Bader,Maria José Campagnole-Santos +6 more
TL;DR: This review highlights the current knowledge about the roles of ANG-(1–7) in physiology and disease, with particular emphasis on the brain.
Journal ArticleDOI
Angiotensin-(1-7) Through Receptor Mas Mediates Endothelial Nitric Oxide Synthase Activation via Akt-Dependent Pathways
Walkyria O. Sampaio,Robson A.S. Santos,Raphael Faria-Silva,Leonor Tapias Machado,Ernesto L. Schiffrin,Rhian M. Touyz +5 more
TL;DR: It is demonstrated that Ang-(1-7), through Mas, stimulates eNOS activation and NO production via Akt-dependent pathways, and the importance of the Ang-( 1-7)/Mas axis as a putative regulator of endothelial function is highlighted.
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Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells.
TL;DR: It is demonstrated that, in human endothelial cells, Ang-(1-7) negatively modulates Ang II/Ang II type 1 receptor–activated c-Src and its downstream targets ERK1/2 and NAD(P)H oxidase, and that SHP-2-c-SRC interaction is enhanced by Ang-( 1-7).
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Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted Mice
Ping Xu,Andrey C. da Costa-Goncalves,Mihail Todiras,Luiza A. Rabelo,Walkyria O. Sampaio,Marina Matos De Moura,Sergio Henrique Sousa Santos,Friedrich C. Luft,Michael Bader,Volkmar Gross,Natalia Alenina,Robson A.S. Santos +11 more
TL;DR: The cardiovascular phenotype of Mas-deficient mice backcrossed onto the FVB/N genetic background using telemetry is studied and it is found that they exhibit higher blood pressures compared with controls and have impaired endothelial function, decreased NO production, and lower endothelial NO synthase expression.
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Systemic and regional hemodynamic effects of angiotensin-(1–7) in rats
TL;DR: The systemic and regional hemodynamics effects of ANG-(1−7) were examined in urethane-anesthetized rats as discussed by the authors, and the blood flow distribution (kidneys, skin, mesentery, lungs, spleen, brain, muscle, and adr...