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Natalia Alenina
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 32
Citations - 4042
Natalia Alenina is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Angiotensin II & Medicine. The author has an hindex of 20, co-authored 20 publications receiving 3648 citations.
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Journal ArticleDOI
Lrp5 functions in bone to regulate bone mass
Yajun Cui,Paul J. Niziolek,Paul J. Niziolek,Bryan T. MacDonald,Cassandra R. Zylstra,Natalia Alenina,Dan R. Robinson,Zhendong Zhong,Susann Matthes,Christina Jacobsen,Ronald A. Conlon,Robert Brommage,Qingyun Liu,Faika Mseeh,David R. Powell,Qi M. Yang,Brian Zambrowicz,Han Gerrits,Jan A. Gossen,Xi He,Michael Bader,Bart O. Williams,Matthew L. Warman,Alexander G. Robling +23 more
TL;DR: Data indicate that Lrp5 signaling functions locally, and they suggest that increasing LRP5 signaling in mature bone cells may be a strategy for treating human disorders associated with low bone mass, such as osteoporosis.
Journal ArticleDOI
Growth retardation and altered autonomic control in mice lacking brain serotonin.
Natalia Alenina,Dana Kikic,Mihail Todiras,Valentina Mosienko,Fatimunnisa Qadri,Ralph Plehm,Philipp Boyé,Larissa Vilianovitch,Reinhard Sohr,Katja Tenner,Heide Hörtnagl,Michael Bader +11 more
TL;DR: Telemetric monitoring revealed more extended daytime sleep, suppressed respiration, altered body temperature control, and decreased blood pressure and heart rate during nighttime in Tph2−/− mice, confirming that the majority of central serotonin is generated by TPH2.
Journal ArticleDOI
Discovery and Characterization of Alamandine A Novel Component of the Renin–Angiotensin System
Roberto Queiroga Lautner,Daniel C. Villela,Rodrigo A. Fraga-Silva,Neiva Caldeira Silva,Thiago Verano-Braga,Fabiana P. Costa-Fraga,Joachim Jankowski,Vera Jankowski,Frederico B. De Sousa,Andréia Carvalho Alzamora,Everton Rocha Soares,Claudiane Maria Barbosa,Frank Kjeldsen,Aline C. Oliveira,Janaina F Braga,Silvia Q Savergnini,Gisele Maia,Antonio A B Peluso,Danielle G. Passos-Silva,Anderson J. Ferreira,Fabiana Alves,Almir S. Martins,Mohan K. Raizada,Renata D. Paula,Daisy Motta-Santos,Friederike Kemplin,Adriano Marçal Pimenta,Natalia Alenina,Rubén D. Sinisterra,Michael Bader,Maria José Campagnole-Santos,Robson A.S. Santos +31 more
TL;DR: Alamandine produces several physiological actions that resemble those produced by angiotensin-(1–7), including vasodilation, antifibrosis, antihypertensive, and central effects and may help to develop new therapeutic strategies for treating human cardiovascular diseases and other related disorders.
Journal ArticleDOI
Platelet-derived serotonin links vascular disease and tissue fibrosis
Clara Dees,Alfiya Akhmetshina,Pawel Zerr,Nicole Reich,Katrin Palumbo,Angelika Horn,Astrid Jüngel,Christian Beyer,Gerhard Krönke,Jochen Zwerina,Rudolf Reiter,Natalia Alenina,Luc Maroteaux,Georg Schett,Oliver Distler,Jörg H W Distler +15 more
TL;DR: Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
Journal ArticleDOI
Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
Valentina Mosienko,Bettina Bert,Daniel Beis,Daniel Beis,Susann Matthes,Susann Matthes,Heidrun Fink,Michael Bader,Natalia Alenina +8 more
TL;DR: These findings provide unequivocal evidence on the pivotal role of central serotonin in anxiety and aggression and the impact of serotonin depletion in the brain on mouse behavior.