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Arnulf Dorn
Researcher at Hoffmann-La Roche
Publications - 34
Citations - 3125
Arnulf Dorn is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Plasmodium falciparum & Haematin. The author has an hindex of 25, co-authored 34 publications receiving 3021 citations. Previous affiliations of Arnulf Dorn include University of Nebraska Medical Center.
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Journal ArticleDOI
Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L. Vennerstrom,Sarah Arbe-Barnes,Reto Brun,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Yuxiang Dong,Arnulf Dorn,Daniel Hunziker,Hugues Matile,Kylie Anne McIntosh,Maniyan Padmanilayam,Josefina Santo Tomas,Christian Scheurer,Bernard Scorneaux,Yuanqing Tang,Heinrich Urwyler,Sergio Wittlin,William N. Charman +18 more
TL;DR: Here it is described how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.
Journal ArticleDOI
Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein
TL;DR: It is shown that, rather than being enzyme-mediated, haem polymerization is actually a chemical process, dependent only on the presence of haem-derived material associated with haemozoin and not on protein.
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An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials
Arnulf Dorn,Sudha Rani Vippagunta,Hugues Matile,Catherine Jaquet,Jonathan L. Vennerstrom,Robert G. Ridley +5 more
TL;DR: A correlation for eight antimalarial quinolines between inhibition of haematin polymerisation in vitro and inhibition of P. falciparum growth in culture is demonstrated, confirming haematar polymerisation as the likely target of quinoline blood schizonticides.
Journal ArticleDOI
4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum.
Robert G. Ridley,Werner Hofheinz,Hugues Matile,Catherine Jaquet,Arnulf Dorn,Raffaello Masciadri,Synese Jolidon,Wolfgang F. Richter,A Guenzi,M A Girometta,H Urwyler,Walter Huber,S Thaithong,W Peters +13 more
TL;DR: An assessment of the activities of four selected compounds containing ethyl, propyl, and isopropyl side chains that retain activity against chloroquine-resistant isolates of Plasmodium falciparum malaria and the formation of N-dealkylated metabolites of these compounds.
Journal ArticleDOI
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.
Sudha Rani Vippagunta,Arnulf Dorn,Hugues Matile,Apurba K. Bhattacharjee,Jean M. Karle,William Y. Ellis,Robert G. Ridley,Jonathan L. Vennerstrom +7 more
TL;DR: Molecular modeling experiments reinforce the view that the enthalpically favorable pi-pi interaction observed in the CQ-hematin mu-oxo dimer complex derives from a favorable alignment of the out-of-plane pi-electron density in CQ and hematinMu-oxe dimer at the points of intermolecular contact.