J
Jörg Benz
Researcher at Hoffmann-La Roche
Publications - 78
Citations - 6848
Jörg Benz is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Antibody & Chemistry. The author has an hindex of 36, co-authored 73 publications receiving 6043 citations. Previous affiliations of Jörg Benz include Max Planck Society & University of Bern.
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Journal ArticleDOI
Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy
Carola Ries,Michael A. Cannarile,Sabine Hoves,Jörg Benz,Katharina Wartha,Valeria Runza,Flora Rey-Giraud,Leon P. Pradel,Friedrich Feuerhake,Irina Klaman,Tobin Jones,Ute Jucknischke,Stefan Scheiblich,Klaus Kaluza,Ingo H. Gorr,Antje Walz,Keelara Abiraj,Philippe A. Cassier,Antonio Sica,Carlos Gomez-Roca,Karin E. de Visser,Antoine Italiano,Christophe Le Tourneau,Jean-Pierre Delord,Hyam I. Levitsky,Jean-Yves Blay,Dominik Rüttinger +26 more
TL;DR: Administration of RG7155 to patients led to striking reductions of CSF-1R(+)CD163(+) macrophages in tumor tissues, which translated into clinical objective responses in diffuse-type giant cell tumor (Dt-GCT) patients.
Journal Article
Annexins: from structure to function.
Jörg Benz,Andreas Hofmann +1 more
TL;DR: A variety of three-dimensional structures of annexin crystals as well as of membrane bound annexins were solved to provide tools to understand the in vivo function of the annexin family.
Journal ArticleDOI
Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose
Claudia Ferrara,Sandra Grau,Christiane Jäger,Peter Sondermann,Peter Brünker,Inja Waldhauer,Michael Hennig,Armin Ruf,Arne C. Rufer,Martine Stihle,Pablo Umana,Jörg Benz +11 more
TL;DR: A detailed, molecular understanding of the regulatory role of Fc-oligosaccharide core fucosylation in improving ADCC is obtained and a unique mechanism by which the immune system can regulate antibody-mediated effector functions is suggested.
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Systematic Investigation of Halogen Bonding in Protein–Ligand Interactions
Leo A. Hardegger,Bernd Kuhn,Beat Spinnler,Lilli Anselm,Robert Ecabert,Martine Stihle,Bernard Gsell,Ralf Thoma,Joachim Diez,Jörg Benz,Jean-Marc Plancher,Guido Hartmann,David Banner,Wolfgang Haap,François Diederich +14 more
TL;DR: During the course of this research, an indication of an XB contact was obtained between a 4-chlorophenyl moiety of a ligand, whose binding affinity was enhanced by a factor of 13 compared to the unsubstituted phenyl derivative, and the backbone C=O group of Gly61 in the S3 pocket (Figure 1).
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Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β
Bernd Bohrmann,Karlheinz Baumann,Jörg Benz,Francoise Gerber,Walter Huber,Frédéric Knoflach,Jürg Messer,Krisztina Oroszlan,Robert Rauchenberger,Wolfgang F. Richter,Christine Rothe,Margit Urban,Michael Bardroff,Michael Winter,Christer Nordstedt,Hansruedi Loetscher +15 more
TL;DR: It is demonstrated that gantenerumab preferentially interacts with aggregated Aβ in the brain and lowers amyloid-β by eliciting effector cell-mediated clearance.