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Wei Qin
Researcher at The Chinese University of Hong Kong
Publications - 3
Citations - 951
Wei Qin is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Fibrosis & Renal fibrosis. The author has an hindex of 3, co-authored 3 publications receiving 858 citations.
Papers
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Journal ArticleDOI
TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29
Wei Qin,Arthur C.K. Chung,Xiao R. Huang,Xiao-Ming Meng,David S.C. Hui,Cheuk-Man Yu,Joseph J.Y. Sung,Hui Y. Lan +7 more
TL;DR: In this paper, using a microRNA microarray and real-time PCR, wild-type mice had reduced expression of miR-29 along with the development of progressive renal fibrosis in obstructive nephropathy.
Journal ArticleDOI
Smad2 Protects against TGF-β/Smad3-Mediated Renal Fibrosis
Xiao-Ming Meng,Xiao R. Huang,Arthur C.K. Chung,Wei Qin,Xinli Shao,Peter Igarashi,Wenjun Ju,Erwin P. Bottinger,Hui Y. Lan +8 more
TL;DR: Conditional deletion of Smad2 from the kidney tubular epithelial cells markedly enhanced fibrosis in response to unilateral ureteral obstruction and protects against TGF-beta-mediated fibrosis by counteracting TGF -beta/Smad3 signaling.
Journal ArticleDOI
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.
TL;DR: Smad4 may be a key regulator for the diverse roles of TGF-β1 in inflammation and fibrogenesis by interacting with Smad7 and Smad3 to influence their transcriptional activities in renal inflammation and Fibrotic response.