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Xiao-Ming Meng
Researcher at Anhui Medical University
Publications - 219
Citations - 12102
Xiao-Ming Meng is an academic researcher from Anhui Medical University. The author has contributed to research in topics: Hepatic stellate cell & Inflammation. The author has an hindex of 40, co-authored 186 publications receiving 8764 citations. Previous affiliations of Xiao-Ming Meng include Chinese Ministry of Education & The Chinese University of Hong Kong.
Papers
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Journal ArticleDOI
TGF-β: the master regulator of fibrosis
TL;DR: Studies over the past 5 years have identified additional mechanisms that regulate the action of TGF-β1/Smad signalling in fibrosis, including short and long noncoding RNA molecules and epigenetic modifications of DNA and histone proteins.
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TGF-β/Smad signaling in renal fibrosis
TL;DR: Targeting TGF-β/Smad3 signaling may represent a specific and effective therapy for CKD associated with renal fibrosis.
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TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29
Wei Qin,Arthur C.K. Chung,Xiao R. Huang,Xiao-Ming Meng,David S.C. Hui,Cheuk-Man Yu,Joseph J.Y. Sung,Hui Y. Lan +7 more
TL;DR: In this paper, using a microRNA microarray and real-time PCR, wild-type mice had reduced expression of miR-29 along with the development of progressive renal fibrosis in obstructive nephropathy.
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Inflammatory processes in renal fibrosis.
TL;DR: Understanding the mechanisms by which inflammation drives renal fibrosis is necessary to facilitate the development of therapeutics to halt the progression of chronic kidney disease.
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Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis
TL;DR: It is demonstrated that Smad3, but not Smad2, signaling increases expression of miR-21, which promotes renal fibrosis, and inhibition of mi R-21 may be a therapeutic approach to suppress renal fibrot.