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Wei Qu
Researcher at National Institutes of Health
Publications - 56
Citations - 4151
Wei Qu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Metallothionein & Arsenic toxicity. The author has an hindex of 33, co-authored 53 publications receiving 3861 citations. Previous affiliations of Wei Qu include Research Triangle Park.
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Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway.
Wei Qu,Hengning Ke,Jingbo Pi,Daniel Broderick,John E. French,Mukta M. Webber,Michael P. Waalkes +6 more
TL;DR: CTPE cells become resistant to apoptosis during malignant transformation, and disruption of the JNK pathway and Bcl-2 overexpression play important roles in this resistance.
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Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
Jie Liu,Lamia Benbrahim-Tallaa,Xun Qian,Limei Yu,Limei Yu,Yaxiong Xie,Jennifer Boos,Wei Qu,Michael P. Waalkes +8 more
TL;DR: Overall, an intricate variety of gene expression changes occur in arsenic-induced malignant transformation of liver cells including oncogene activation and alterations in expression of genes critical to growth regulation.
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Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure
Wei Qu,Michael P. Waalkes +1 more
TL;DR: Overall, MT protects against arsenic-induced ODD in MT competent cells by potential sequestration of scavenging oxidant radicals and/or arsenic.
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Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells.
TL;DR: Chronic cadmium exposure produced multiple tumor cell characteristics in HPDE cells and CCE cell–derived spheres, which support the plausibility of Cadmium as a human pancreatic carcinogen.
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The Nitric Oxide Donor, O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), Protects against Cadmium-Induced Hepatotoxicity in Mice
TL;DR: The liver-selective NO donor, V-PYRRO/NO, protects against Cd hepatotoxicity in mice and may be related to reduced hepatic inflammation, reduced acute phase responses, and the suppression of cell-death-related components.