W
Wei Sun
Researcher at Yale University
Publications - 7
Citations - 601
Wei Sun is an academic researcher from Yale University. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 7, co-authored 7 publications receiving 591 citations.
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Journal ArticleDOI
Borrelia burgdorferi genes selectively expressed in the infected host
Kyoungho Suk,Subrata Das,Wei Sun,Biru Jwang,Stephen W. Barthold,Richard A. Flavell,Erol Fikrig +6 more
TL;DR: An immunological screening strategy was used to select microbial genes expressed only in the host to identify genes induced in vivo in a wide variety of pathogenic microorganisms for which a gene transfer system is not currently available.
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Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity
TL;DR: The use of in vivo-expressed antigens such as P35 and P37 represents a new approach for Lyme disease serodiagnosis and for understanding the role of B. burgdorferi-specific immune responses in host immunity.
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Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response.
TL;DR: The gene encoding the 44-kDa protein of the agent of HGE (aoHGE), hge-44, is part of a multigene family, with sequence similarity to the Anaplasma marginale msp-2 genes, and is expressed and elicits specific antibodies during infection.
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Granulocytic ehrlichiosis in the laboratory mouse
Emir Hodzic,Jacob W. IJdo,Sunlian Feng,Paula Katavolos,Wei Sun,Craig H Maretzki,Durland Fish,Erol Fikrig,Sam R. Telford,Stephen W. Barthold +9 more
TL;DR: All assays detected the HGE agent in blood during early infection, but PCR and the mouse infectivity assay were most sensitive during late infection, and Xenodiagnosis demonstrated that mice remain persistently infected through 55 days.
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Immunization against the agent of human granulocytic ehrlichiosis in a murine model.
TL;DR: Data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE, a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes.