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Wei Wang
Researcher at Wuhan University
Publications - 66
Citations - 3380
Wei Wang is an academic researcher from Wuhan University. The author has contributed to research in topics: Catalysis & Hydrogen bond. The author has an hindex of 22, co-authored 63 publications receiving 2920 citations. Previous affiliations of Wei Wang include Southern Illinois University Carbondale & University of Pittsburgh.
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Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
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Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Grzegorz M. Popowicz,Anna Czarna,Siglinde Wolf,Kan Wang,Wei Wang,Alexander Dömling,Tad A. Holak +6 more
TL;DR: The structures indicate how the substituents of a small molecule that bind to the three subpockets of theMDM2/X-p53 interaction should be optimized for effective binding to MDM2 and/or MDMX.
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The linear neighborhood propagation method for predicting long non-coding RNA–protein interactions
TL;DR: The study shows that the LPLNP model based on the known lncRNA–protein interactions can produce high-accuracy performances, and can be validated, indicating that the method is a useful tool for lnc RNA–protein interaction prediction.
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Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists
David Ryan Koes,Kareem Khoury,Yijun Huang,Wei Wang,Michal Bista,Grzegorz M. Popowicz,Siglinde Wolf,Tad A. Holak,Alexander Dömling,Carlos J. Camacho +9 more
TL;DR: A novel pharmacophore-based interactive screening technology that builds on the role anchor residues, or deeply buried hot spots, have in PPIs, and redesigns these entry points with anchor-biased virtual multicomponent reactions, delivering tens of millions of readily synthesizable novel compounds.
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Chemistry and Biology of Multicomponent Reactions
TL;DR: Multicomponent reactions (MCRs) as discussed by the authors are one-pot reactions employing more than two starting materials, where most of the atoms of the starting materials are incorporated in the final product.