다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

The influence of diet on the distribution of nitrogen isotopes in animals was investigated by analyzing animals grown in the laboratory on diets of constant nitrogen isotopic composition. 
The isotopic composition of the nitrogen in an animal reflects the nitrogen isotopic composition of its diet. The δ^(15)N values of the whole bodies of animals are usually more positive than those of their diets. Different individuals of a species raised on the same diet can have significantly different δ^(15)N values. The variability of the relationship between the δ^(15)N values of animals and their diets is greater for different species raised on the same diet than for the same species raised on different diets. Different tissues of mice are also enriched in ^(15)N relative to the diet, with the difference between the δ^(15)N values of a tissue and the diet depending on both the kind of tissue and the diet involved. The δ^(15)N values of collagen and chitin, biochemical components that are often preserved in fossil animal remains, are also related to the δ^(15)N value of the diet. 
The dependence of the δ^(15)N values of whole animals and their tissues and biochemical components on the δ^(15)N value of diet indicates that the isotopic composition of animal nitrogen can be used to obtain information about an animal's diet if its potential food sources had different δ^(15)N values. The nitrogen isotopic method of dietary analysis probably can be used to estimate the relative use of legumes vs non-legumes or of aquatic vs terrestrial organisms as food sources for extant and fossil animals. However, the method probably will not be applicable in those modern ecosystems in which the use of chemical fertilizers has influenced the distribution of nitrogen isotopes in food sources. 
The isotopic method of dietary analysis was used to reconstruct changes in the diet of the human population that occupied the Tehuacan Valley of Mexico over a 7000 yr span. Variations in the δ^(15)C and δ^(15)N values of bone collagen suggest that C_4 and/or CAM plants (presumably mostly corn) and legumes (presumably mostly beans) were introduced into the diet much earlier than suggested by conventional archaeological analysis.

Influence of Diet On the Distribtion of Nitrogen Isotopes in Animals

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Abstract A two-dimensional version of the Pennsylvania State University mesoscale model has been applied to Winter Monsoon Experiment data in order to simulate the diurnally occurring convection observed over the South China Sea. The domain includes a representation of part of Borneo as well as the sea so that the model can simulate the initiation of convection. Also included in the model are parameterizations of mesoscale ice phase and moisture processes and longwave and shortwave radiation with a diurnal cycle. This allows use of the model to test the relative importance of various heating mechanisms to the stratiform cloud deck, which typically occupies several hundred kilometers of the domain. Frank and Cohen's cumulus parameterization scheme is employed to represent vital unresolved vertical transports in the convective area. The major conclusions are: Ice phase processes are important in determining the level of maximum large-scale heating and vertical motion because there is a strong anvil componen...

Numerical study of convection observed during the Winter Monsoon Experiment using a mesoscale two-dimensional model [presentation]

Long Term Downhole Wet-connector Technology for Separate Injection Well - A Case Study in Changqing Oil Field

Chuifeng Cave is one of the typical representatives of the Gigantopithecus-bearing mammalian assemblages in southern China. The Chuifeng mammalian assemblage, including 92 Gigantopithecus blacki teeth fossils, is important to construct the biochronological and paleobiogeographic framework for the Pleistocene mammalian assemblage in mainland Southeast Asia. Except for the G. blacki teeth fossils, the left 721 identified mammalian fossils have never been described in detail until now. Here, we present taxonomic descriptions of the rest mammalian fossils from Chuifeng Cave. The Chuifeng mammalian assemblage consists at least of 28 large mammal taxa, including the Neogene relict species, Sinomastodon sp. and Hippopotamodon ultimus, and the species for their first appearances in the Pleistocene, Hystrix magna, Stegodon huananensis, Ailuropoda microta, Rhinoceros fusuiensis, Tapirus sanyuanensis, Sus peii, Sus xiaozhu, Cervus fenqii and Megalovis guangxiensis. Comparisons to already-dated early Pleistocene mammalian assemblages in southern China indicate that the age of this assemblage is around 1.9 Ma, which is consistent with the ESR/U-series and paleomagnetic dating results. The occurrences of Equus in the Chuifeng, Liucheng Gigantopithecus, Longgudong and Longgupo sites imply that G. blacki may survive in an open woodland environment with grasslands nearby in the middle and north parts of southern China. 

Early Pleistocene large-mammal assemblage associated with Gigantopithecus at Chuifeng Cave, Bubing Basin, South China

Cloud computing is a computing model, computing and storage tasks be assigned to the cloud that be composed of a large number of computers. The cloud computing technology are introduced firstly, then the cloud network platform, the service platform for barrier-free special education and functions are detailed described, lastly the key technology is given, such as TTS technology, Microsoft Speech SDK.

The Service Platform for Barrier-Free Special Education Based on Cloud Computing

Objectives To investigate the effect of adriamycin (ADM), idelalisib or ADM and their combination on cell proliferation and intracellular concentration of ADM, and to explore the reversal effect of idelalisib on drug resistance to ADM. Methods The K562 and K562/ADM cells were respectively treated with ADM and idelalisib at different concentrations. The 50% inhibitory concentration (IC50) and drug resistance index (RI) of ADM to the 2 kinds of cells were measured by methyl thiazolyl tetrazolium (MTT) assay. Non-cytotoxic dose (cell inhibition rate Results The cell survival rates were significantly decreased in a dose-dependent manner when the cells were treated with different doses of ADM (0.001-10.000 mg/L ). The IC50 value of ADM in the K562 and K562/ADM cells were 0.2 mg/L and 1.0 mg/L, respectively. The RI value was 5. The cell survival rates were also significantly decreased in a dose-dependent manner when the cells were treated with different doses of idelalisib (1-50 μmol/L). The non-cytotoxic dose of idelalisib in the K562 and K562/ADM cells were 25 μmol/L and 15 μmol/L, respectively. The cell survival rates in the ADM+ idelalisib group was less than that in the ADM group (P 0.05). The intracellular ATP level in the K562 cells was about (91.502±0.479) mmol/L, and that in the K562/ADM cells was about (24.311±0.349) mmol/L. The intracellular ATP level in the ADM+ idelalisib group in the K562/ADM cells was less than that in the ADM group (P 0.05). The absorption of intracellular ADM in the ADM + idelalisib group in the K562/ADM cells was more than that in the ADM group (P 0.05). The exclusion of intracellular ADM in the ADM + idelalisib group in the K562/ADM cells was less than that in the ADM group (P 0.05). Conclusions Idelalisib exerts effect on inhibition of the proliferation in myeloid leukemia K562 and K562/ADM cells, which may partially reverse the drug resistance of K562/ADM cells to ADM. The mechanisms for the effect of idelalisib may be related to increasing the accumulation of ADM and inducing the cell apoptosis in the K562 and K562/ADM cells.

Inhibitory effect of PI3Kδ inhibitor idelalisib on proliferation of human myeloid leukemia cells and the reversal effect on drug resistance to adriamycin.

In this paper, a discrimination method is proposed for the interturn short-circuit and resistive unbalance faults of the synchronous condenser. The mathematical models of the synchronous condenser are established under these two faults. Especially, the zero-sequence voltage components (ZSVC) under two faults are analyzed. Due to the direct connection between the synchronous condenser and the power grid, the fundamental component of ZSVC under the interturn short-circuit fault is not affected by the stator currents, while the resistive unbalance fault is just the opposite. Hence, the amplitude of fundamental component in ZSVC is used to detect the fault occurrence. Then, the change of the fundamental component in ZSVC is observed by changing the excitation current to discriminate the fault type. The effectiveness of the proposed method is verified by the simulation and experimental results.

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Wei Wang

Papers

Long Term Downhole Wet-connector Technology for Separate Injection Well - A Case Study in Changqing Oil Field

Early Pleistocene large-mammal assemblage associated with Gigantopithecus at Chuifeng Cave, Bubing Basin, South China

The Service Platform for Barrier-Free Special Education Based on Cloud Computing

Inhibitory effect of PI3Kδ inhibitor idelalisib on proliferation of human myeloid leukemia cells and the reversal effect on drug resistance to adriamycin.

Discrimination Method of Interturn Short-Circuit and Resistive Unbalance Faults for Synchronous Condenser