Wei Xiao

TL;DR: It is proposed that increased uPAR expression in the small airway epithelium of patients with COPD participates in an active EMT process and it is demonstrated that the PI3K/Akt signaling pathway is required for uPAR-mediated EMT in HSAEpiCs.

TL;DR: This consensus statement describes the pathogenesis, clinical features, and the management of airway mucus hypersecretion in patients with chronic airway inflammatory diseases in the People’s Republic of China.

TL;DR: Ambient air pollution is correlated with AECOPD hospitalizations spatially, with only the PM10 concentrations at workplace showed statistical significance, with a 10 μg/m(3) increase at workplace associated with a 7% (95%CI: [3.3%, 10%]) increase of hospitalizations due to AECopD in Jinan, 2009.

TL;DR: It is found that increased induced sputum levels of LL-37 in COPD patients were associated with airflow limitation, health status and exercise tolerance and the expressing intensity of LL -37 in both airway district and pulmonary alveoli area in COPd group significantly increased compared with control group.

TL;DR: After cigarette smoke exposure, the increased levels of LL-37 in airway epithelium could stimulate collagen production in the underlying lung fibroblasts and may contribute to small airway remodeling in COPD.