W
Weidong Yang
Researcher at University of Maryland, Baltimore
Publications - 11
Citations - 3434
Weidong Yang is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Multiple drug resistance & Abcg2. The author has an hindex of 10, co-authored 11 publications receiving 3235 citations. Previous affiliations of Weidong Yang include University of Maryland Marlene and Stewart Greenebaum Cancer Center.
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Journal Article
Quantitative Analysis of Breast Cancer Resistance Protein and Cellular Resistance to Flavopiridol in Acute Leukemia Patients
Takeo Nakanishi,Judith E. Karp,Ming Tan,L. Austin Doyle,Todd Peters,Weidong Yang,David Wei,Douglas D. Ross +7 more
TL;DR: The results suggest that unlike P-gp, BCRP may play a role in leukemia cellular resistance to flavopiridol.
Journal ArticleDOI
An etoposide-resistant lung cancer subline overexpresses the multidrug resistance-associated protein.
L. A. Doyle,Douglas D. Ross,J. V. Ordonez,Weidong Yang,Y. Gao,Y. Tong,Chandra P. Belani,J. C. Gutheil +7 more
TL;DR: It is indicated that MRP gene expression may be induced by etoposide and may lead to reduced accumulation of the drug.
Journal Article
H19 Gene Overexpression in Atypical Multidrug-resistant Cells Associated with Expression of a 95-Kilodalton Membrane Glycoprotein
TL;DR: This is the first report of H19 gene overexpression accompanying any form of drug resistance, and another p95-overexpressing multidrug-resistant cell line, human lung carcinoma NCI-H1688, also displays high levels of H 19 mRNA.
Journal Article
The 95-kilodalton membrane glycoprotein overexpressed in novel multidrug-resistant breast cancer cells is NCA, the nonspecific cross-reacting antigen of carcinoembryonic antigen.
TL;DR: It is suggested that the overexpression of CEA, possibly in combination with that of NCA-90, could account at least in part for the drug resistant phenotype displayed by MCF-7/AdrVp cells.
ACCELERATED DISCOVERY Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone- Selected Cell Lines
Douglas D. Ross,Weidong Yang,Lynne V. Abruzzo,William S. Dalton,Hermann Lage,Manfred Dietel,Lee Greenberger,Susan P.C. Cole,L. Austin Doyle +8 more
TL;DR: Overexpression of BCRP mRNA is frequently observed in multidrug-resistant cell lines selected with mitoxantrone, suggesting that B CRP is likely to be a major cellular defense mechanism elicited in response to exposure to this drug.