T
Takeo Nakanishi
Researcher at Takasaki University of Health and Welfare
Publications - 165
Citations - 7867
Takeo Nakanishi is an academic researcher from Takasaki University of Health and Welfare. The author has contributed to research in topics: Organic anion-transporting polypeptide & Organic anion transporter 1. The author has an hindex of 49, co-authored 160 publications receiving 7107 citations. Previous affiliations of Takeo Nakanishi include University of Maryland, Baltimore & Georgia Regents University.
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Journal ArticleDOI
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
Partha Krishnamurthy,Douglas D. Ross,Douglas D. Ross,Takeo Nakanishi,Kim Bailey-Dell,Sheng Zhou,Kelly E. Mercer,Balázs Sarkadi,Brian P. Sorrentino,John D. Schuetz +9 more
TL;DR: The studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions and suggest that cells can, upon hypoxic demand, use BCRP to reduce heme or porphyrin accumulation, which can be detrimental to cells.
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Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer.
Khine Myint,Riya Biswas,Yan Li,Nancy N. Jong,Stephen M. F. Jamieson,Johnson J. Liu,Catherine H. Han,Christopher J. Squire,Fabrice Merien,Jun Lu,Takeo Nakanishi,Ikumi Tamai,Mark J. McKeage +12 more
TL;DR: Screening tumour MRP2 expression levels, to select patients for treatment with oxaliplatin-based chemotherapy alone or in combination with a MRP1 inhibitor, could improve treatment outcomes and limit oxali platin accumulation and response in human gastrointestinal cancer.
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SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria
Yukihiro Chino,Yukihiro Chino,Yoshishige Samukawa,Soichi Sakai,Yasuhiro Nakai,Junichi Yamaguchi,Takeo Nakanishi,Ikumi Tamai +7 more
TL;DR: It was demonstrated that the UEUA could potentially be increased by luseogliflozin‐induced glycosuria, with alterations of UA transport activity because of urinary glucose.
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Cloning of an Amino Acid Transporter with Functional Characteristics and Tissue Expression Pattern Identical to That of System A
Mitsuru Sugawara,Takeo Nakanishi,You-Jun Fei,Wei Huang,Malliga E. Ganapathy,Frederick H. Leibach,Vadivel Ganapathy +6 more
TL;DR: The cloning and functional characterization of the protein responsible for the system A amino acid transport activity, designated ATA2 for amino acid transporter A2, was cloned from rat skeletal muscle, represents a significant step toward understanding the function and expression of this transporter in various physiological and pathological states.
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Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression.
Takeo Nakanishi,Douglas D. Ross +1 more
TL;DR: A synopsis of the impact of BCRP-mediated MDR in cancer cells, and the molecular mechanisms of acquired MDR currently postulated in a variety of human cancers are presented.