Weiping Zhu

TL;DR: A highly selective and sensitive OFF-ON fluorescent sensor 1, employing the PET mechanism, was designed and synthesized and could be used to detect Cd(2+) ion in aqueous solution and to image Cd (2+) ion in living cells.

TL;DR: A FRET-based small-molecule fluorescent probe (PNCy3Cy5) is developed, harnessing the differential reactivity of Cy3 and Cy5 toward OONO(-) by fine-tuning and exhibits high detection sensitivity and yields a ratiometric fluorescent signal.

TL;DR: A new ratiometric fluorescence probe E1 based on an excited-state intramolecular proton transfer (ESIPT) mechanism for detection of hydrogen sulfide (H(2)S) is reported and showed a 30-fold fluorescence enhancement in 2 minutes.

TL;DR: Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) was designed and synthesized and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescentRatiometric probe for Hypoxia in solid tumors.

TL;DR: A new paradigm was suggested for the design of novel multitarget anticancer drugs after a new class of naphthalimides was designed, synthesized, and proved to inhibit topoisomerase II, induced lysosomal membrane permeabilization, and ultimately caused apoptosis and cell death.