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Weizhong Zhu
Researcher at Nantong University
Publications - 70
Citations - 5143
Weizhong Zhu is an academic researcher from Nantong University. The author has contributed to research in topics: Signal transduction & Ca2+/calmodulin-dependent protein kinase. The author has an hindex of 34, co-authored 69 publications receiving 4770 citations. Previous affiliations of Weizhong Zhu include Thomas Jefferson University & Peking University.
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Journal ArticleDOI
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
TL;DR: In this article, the authors investigate the role of β-adrenergic receptor (AR) and β-AR subtypes in regulating cardiomyocyte survival and apoptosis and explore underlying mechanisms.
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Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
Weizhong Zhu,Shi-Qiang Wang,Khalid Chakir,Dongmei Yang,Tong Zhang,Joan Heller Brown,Eric Devic,Brian K. Kobilka,Heping Cheng,Rui-Ping Xiao +9 more
TL;DR: CaMKII constitutes a novel PKA-independent linkage of beta(1)AR stimulation to cardiomyocyte apoptosis that has been implicated in the overall process of chronic heart failure, and is associated with non-PKA-dependent increases in intracellular Ca(2+) and CaMKII activity.
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Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology.
Ying Ying Zhou,Shi-Qiang Wang,Weizhong Zhu,Andrej Chruscinski,Brian K. Kobilka,Bruce D. Ziman,Su Wang,Edward G. Lakatta,Heping Cheng,Rui-Ping Xiao +9 more
TL;DR: Adenovirus-directed expression of either beta(1)- or beta(2)-AR, which occurred in 100% of cells, rescued the functional response to beta-AR agonist stimulation and modified and improved current enzymatic methods to isolate a high yield of high-quality adult mouse myocytes.
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High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca2+ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells
Tatiana M. Vinogradova,Alexey E. Lyashkov,Weizhong Zhu,Abdul M. Ruknudin,Syevda Sirenko,Dongmei Yang,Shekhar H. Deo,Matthew A. Barlow,Shavsha Johnson,James L. Caffrey,Ying Ying Zhou,Ying Ying Zhou,Rui-Ping Xiao,Heping Cheng,Michael D. Stern,Victor A. Maltsev,Edward G. Lakatta +16 more
TL;DR: It is shown that a high basal cAMP level of isolated rabbit SANC and its attendant increase in protein kinase A (PKA)-dependent phosphorylation are obligatory for the occurrence of spontaneous, basal LCRs and for spontaneous beating and is crucial for both basal and reserve cardiac pacemaker function.
Journal ArticleDOI
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.
Qiang Zhou,Jianmin Xiao,Jianmin Xiao,Dawei Jiang,Ruiwu Wang,Kannan Vembaiyan,Aixia Wang,Christopher Smith,Cuihong Xie,Cuihong Xie,Cuihong Xie,Wenqian Chen,Jingqun Zhang,Xixi Tian,Peter P. Jones,Peter P. Jones,Xiaowei Zhong,Ang Guo,Haiyan Chen,Lin Zhang,Weizhong Zhu,Dongmei Yang,Xiaodong Li,Ju Chen,Anne M. Gillis,Henry J. Duff,Heping Cheng,Heping Cheng,Arthur M. Feldman,Long-Sheng Song,Michael Fill,Thomas G. Back,S. R. Wayne Chen,S. R. Wayne Chen +33 more
TL;DR: It is shown that carvedilol is the only beta blocker tested that effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2) and this unique anti-SOICR activity of carveilol probably contributes to its favorable antiarrhythmic effect.