L
Long-Sheng Song
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 139
Citations - 12063
Long-Sheng Song is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Ryanodine receptor & Ryanodine receptor 2. The author has an hindex of 47, co-authored 123 publications receiving 10879 citations. Previous affiliations of Long-Sheng Song include University of Iowa & United States Department of Veterans Affairs.
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Journal ArticleDOI
Correction: Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases
Yuejin Wu,Tyler P. Rasmussen,Olha M. Koval,Mei-ling A. Joiner,Duane D. Hall,Biyi Chen,Elizabeth D. Luczak,Qiongling Wang,Adam G. Rokita,Xander H.T. Wehrens,Long-Sheng Song,Mark E. Anderson +11 more
TL;DR: In Fig. 4c of this Article, the y axis values were wrongly given as 0, 20, 40, 60 and 80 in the middle and the lower panels.
Journal ArticleDOI
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Peter J. Mohler,Jean-Jacques Schott,Anthony O. Gramolini,Keith W. Dilly,Silvia Guatimosim,William H. duBell,Long-Sheng Song,Karine Haurogné,Florence Kyndt,Mervat E. Ali,Terry B. Rogers,W. J. Lederer,Denis Escande,Hervé Le Marec,Vann Bennett,Vann Bennett +15 more
TL;DR: It is reported that a loss-of-function (E1425G) mutation in ankyrin-B, a member of a family of versatile membrane adapters, causes dominantly inherited type 4 long-QT cardiac arrhythmia in humans.
Journal ArticleDOI
FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death
Xander H.T. Wehrens,Stephan E. Lehnart,Fannie Huang,John A. Vest,Steven Reiken,Peter J. Mohler,Jie Sun,Silvia Guatimosim,Long-Sheng Song,Nora Rosemblit,Jeanine D'Armiento,Carlo Napolitano,Mirella Memmi,Silvia G. Priori,W. J. Lederer,Andrew R. Marks +15 more
TL;DR: It is shown that during exercise, RyR2 phosphorylation by cAMP-dependent protein kinase A (PKA) partially dissociates FKBP12.6 from the channel, increasing intracellular Ca(2+) release and cardiac contractility, suggesting that "leaky"RyR2 channels can trigger fatal cardiac arrhythmias.
Journal ArticleDOI
Calmodulin kinase II inhibition protects against structural heart disease
Rong Zhang,Michelle S.C. Khoo,Yuejin Wu,Yingbo Yang,Chad E. Grueter,Gemin Ni,Edward Price,William H. Thiel,Silvia Guatimosim,Silvia Guatimosim,Long-Sheng Song,Ernest C. Madu,Anisha N Shah,Tatiana A. Vishnivetskaya,James B. Atkinson,Vsevolod V. Gurevich,Guy Salama,W. J. Lederer,Roger J. Colbran,Mark E. Anderson +19 more
TL;DR: CaMKII inhibition substantially prevented maladaptive remodeling from excessive βAR stimulation and myocardial infarction, and induced balanced changes in excitation-contraction coupling that preserved baseline and βAR-stimulated physiological increases in cardiac function.
Journal ArticleDOI
Calcium flickers steer cell migration
TL;DR: Findings show how the exquisite spatiotemporal organization of calcium microdomains can orchestrate complex cellular processes such as cell migration.