Wen-Bang Yu

TL;DR: It is demonstrated that the nitrogen regulator GlnR of the actinomycete Saccharopolyspora erythraea directly regulates transcription of the acuA gene, which encodes a Gcn5-type lysine acetyltransferase, a signaling cascade that acts from nutrient sensing to acetylation of proteins to feedback regulation.

TL;DR: Comparison of the functional comparative genomics between an industrial S. erythraea strain and the wild-type strain helps to understand the global regulation mechanisms of eryhromycin biosynthesis and feeder pathways in S.ÂerythRAea, providing useful clues for genetic and metabolic engineering in the future.

TL;DR: It is found that σw, an extracytoplasmic function sigma factor, plays an important role in the resistance to fusaricidins during the initial 5 minutes of drug addition.

TL;DR: The transcriptome data analysis revealed that low oxygen supply has three major effects on metabolism: enhance carbon metabolism, inhibit degradation of nitrogen sources (glutamate family amino acids and xanthine) and purine synthesis, which provide new insights into the relationship between oxygen supply and metabolism.

TL;DR: The results revealed the common and distinct modes of action of these three amino acids, and should help to elucidate the specific signaling mechanism of each amino acid as an effector.