Bang-Ce Ye

TL;DR: The duplex-specific nuclease is employed to recycle the process of target-assisted digestion of Taqman probes, resulting in a significant fluorescence signal amplification through which one target molecule cleaves thousands of probe molecules, and the efficiency of this DSNSA strategy for rapid direct quantification of multiple miRNAs in biological samples is demonstrated.

TL;DR: A novel highly sensitive and selective fluorescence polarization assay (FPA) method for the detection of Hg ions on the basis of the formation of T–Hg–T complexes is presented.

TL;DR: This work rationally engineered an elegant entropy-driven DNA nanomachine with three-dimensional track that outperforms the conventional intermolecular reaction-based gold nanoparticle design in the context of an improved sensitivity and kinetics, attributed to the enhanced local effective concentrations of working DNA components from the proximity-induced intramolecular Reaction.

TL;DR: An effective dual-DNAzyme-based unimolecular probe design employing intramolecular signal transduction is demonstrated, and may provide the basis for future development of other nucleic acid-based probes for toxicological and environmental monitoring.

TL;DR: This hybrid microfluidic system integrated with aptamer-functionalized graphene oxide (GO) nano-biosensors for simple, one-step, multiplexed pathogen detection and has great potential in rapid detection of a wide variety of different other bacterial and viral pathogens.