W
Wen Liu
Researcher at Rockefeller University
Publications - 8
Citations - 657
Wen Liu is an academic researcher from Rockefeller University. The author has contributed to research in topics: Amino acid & Peptide. The author has an hindex of 6, co-authored 8 publications receiving 638 citations.
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Journal ArticleDOI
Disulfide bond formation in peptides by dimethyl sulfoxide. Scope and applications
Journal ArticleDOI
Chemically unambiguous peptide immunogen: preparation, orientation and antigenicity of purified peptide conjugated to the multiple antigen peptide system.
TL;DR: A novel and simple approach to prepare chemically unambiguous peptide immunogen using the multiple antigen peptide (MAP) approach, which provides a clear explanation for the specificity of the antipeptide antibodies and their failure to recognize the "reverse immunogen".
Journal ArticleDOI
Alanine scan of endothelin: Importance of aromatic residues
James P. Tam,Wen Liu,Jing-Wen Zhang,Mauro Galantino,Federico Bertolero,Cinzia Cristiani,Fabrizio Vaghi,Roberto De Castiglione +7 more
TL;DR: A systematic approach to map the functional important determinants of endothelin-1 by an alanine scan is described, finding that residues Asp8, Tyr13, Phe14, Leu17, and Trp21 were of major biological significance and can be considered to be important for signal transduction.
Journal ArticleDOI
Mapping the receptor-recognition site of human transforming growth factor-α
TL;DR: Results show that determinants for the receptor binding cannot be represented by a short continuous fragment or a single subdomain, but are located on a discontinuous surface on a folded structure with disulfide restraints.
Alanine Scan of Endothelin
TL;DR: In this paper, a series of analogs was synthesized by SPPS, using the Boc-benzyl protecting group strategy, in order to get an insight into the endothelin's structural requirements for vasoconstrictor activity.