다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis of cancer, respectively. By taking advantage of nanocarriers, both imaging and therapeutic functions together with enhanced tumour accumulation have been thoroughly studied to improve the pre-clinical efficiency of PAI and PTT. In this review, we first summarize the development of inorganic and organic nano photothermal transduction agents (PTAs) and strategies for improving the PTT outcomes, including applying appropriate laser dosage, guiding the treatment via imaging techniques, developing PTAs with absorption in the second NIR window, increasing photothermal conversion efficiency (PCE), and also increasing the accumulation of PTAs in tumours. Second, we introduce the advantages of combining PTT with other therapies in cancer treatment. Third, the emerging applications of PAI in cancer-related research are exemplified. Finally, the perspectives and challenges of PTT and PAI for combating cancer, especially regarding their clinical translation, are discussed. We believe that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve our ability to combat cancers.

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Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Organic materials that exhibit thermally activated delayed fluorescence (TADF) are an attractive class of functional materials that have witnessed a booming development in recent years. Since Adachi et al. reported high-performance TADF-OLED devices in 2012, there have been many reports regarding the design and synthesis of new TADF luminogens, which have various molecular structures and are used for different applications. In this review, we summarize and discuss the latest progress concerning this rapidly developing research field, in which the majority of the reported TADF systems are discussed, along with their derived structure–property relationships, TADF mechanisms and applications. We hope that such a review provides a clear outlook of these novel functional materials for a broad range of scientists within different disciplinary areas and attracts more researchers to devote themselves to this interesting research field.

Recent advances in organic thermally activated delayed fluorescence materials.

Design strategies for water-soluble small molecular chromogenic and fluorogenic probes.

The cyanine platforms including cyanine, hemicyanine, and squaraine are good candidates for developing chemosensors because of their excellent photophysical properties, outstanding biocompatibility, and low toxicity to living systems. A huge amount of research work involving chemosensors based on the cyanine platforms has emerged in recent years. This review focuses on the development from 2000 to 2015, in which cyanine, hemicyanine, and squaraine sensors will be separately summarized. In each section, a systematization according to the type of detection mechanism is established. The basic principles about the design of the chemosensors and their applications as bioimaging agents are clearly discussed. In addition, we emphasize the advances that have been made in improving the detection performance through incorporation of the chemosensors into nanoparticles.

Recent Development of Chemosensors Based on Cyanine Platforms

Traditional photothermal therapy requires high-intensity laser excitation for cancer treatments due to the low photothermal conversion efficiency (PCE) of photothermal agents (PTAs). PTAs with ultra-high PCEs can decrease the required excited light intensity, which allows safe and efficient therapy in deep tissues. In this work, a PTA is synthesized with high PCE of 88.3% based on a BODIPY scaffold, by introducing a CF3 "barrier-free" rotor on the meso-position (tfm-BDP). In both the ground and excited state, the CF3 moiety in tfm-BDP has no energy barrier to rotation, allowing it to efficiently dissipate absorbed (NIR) photons as heat. Importantly, the barrier-free rotation of CF3 can be maintained after encapsulating tfm-BDP into polymeric nanoparticles (NPs). Thus, laser irradiation with safe intensity (0.3 W cm-2 , 808 nm) can lead to complete tumor ablation in tumor-bearing mice after intravenous injection of tfm-BDP NPs. This strategy of "barrier-free rotation" provides a new platform for future design of PTT agents for clinical cancer treatment.

NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy.

Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy and diagnostics, CDs are good candidates when they are combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development of CDs in nanomedicine is reviewed from their use as original imaging agents and/or drug carriers to multifunctional theranostic systems. Finally, the challenges and prospects of the next-generation of CD-based theranostics for clinical applications are also discussed.

Carbon Dots for In Vivo Bioimaging and Theranostics.

A two-photon fluorescent probe with near-infrared emission for hydrogen sulfide imaging in biosystems.

The emergence of massive Internet of Things (IoT) mobile devices (MDs) and the deployment of ultradense 5G cells have promoted the evolution of IoT toward ultradense IoT networks. In order to meet the diverse quality-of-service and quality of experience demands from the ever-increasing IoT applications, the ultradense IoT networks face unprecedented challenges. Among them, a fundamental one is how to address the conflict between the resource-hungry IoT mobile applications and the resource-constrained IoT MDs. By offloading the IoT MDs’ computation tasks to the edge servers deployed at the radio access infrastructures, including macro base station (MBS) and small cells, mobile-edge computation offloading (MECO) provides us a promising solution. However, note that available MECO research mostly focused on single-tier base station scenario and computation offloading between the MDs and the edge server connected to the MBS. Little works can be found on performing MECO in ultradense IoT networks, i.e., a multiuser ultradense edge server scenario. Toward this end, we provide this paper to study the MECO problem in ultradense IoT networks, and propose a two-tier game-theoretic greedy offloading scheme as our solution. Extensive numerical results corroborate the superior performance of conducting computation offloading among multiple edge servers in ultradense IoT networks.

Wen Sun

Papers

Recent Development of Chemosensors Based on Cyanine Platforms

NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy.

Carbon Dots for In Vivo Bioimaging and Theranostics.

A two-photon fluorescent probe with near-infrared emission for hydrogen sulfide imaging in biosystems.

Mobile-Edge Computation Offloading for Ultradense IoT Networks