Wencheng Xia

TL;DR: It is suggested that phase separation is an intrinsic property of Hsp40 proteins, which enables efficient incorporation and function of HSp40 in membraneless organelles and may further mediate the buildup of chaperone network in membrAneless organlles.

TL;DR: In this article , two RNA-binding proteins, RBGD2 and RBGD4, function redundantly to improve heat resistance in Arabidopsis and showed that modifying these proteins by mutating TRA abolishes their condensation in SGs and impairs their protective function against heat stress.

TL;DR: Cryo-electron microscopy is used to determine the amyloid fibril structure formed by hnRNPA1 LC domain and reveals that the nuclear localization sequence of hn RNPA1 (termed PY-NLS), which is initially known to mediate the nucleo-cytoplamic transport of hsRNA A1 through binding with karyopherin-β2 (Kapβ2), represents the major component of the fibrils core.

TL;DR: In this paper, the structure of the G51D alpha-synuclein fibril was determined using a 2.96 angstrom resolution, which is a relatively small and extended serpentine fold.

TL;DR: In this paper, the interplay between hereditary mutant and wild-type α-syn and its role in the exacerbated pathology of αsyn in fPD progression is poorly understood, and the authors find that WT mice inoculated with the human E46K mutant αsyn fibril (hE46K) strain develop early onset and rapid progression of familial Parkinson's diseases (fPD).