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Wenfei Song
Researcher at Tsinghua University
Publications - 6
Citations - 1293
Wenfei Song is an academic researcher from Tsinghua University. The author has contributed to research in topics: Chemistry & Protein structure. The author has an hindex of 3, co-authored 4 publications receiving 1033 citations.
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Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
TL;DR: Structural comparisons suggested that the SARS-CoV S glycoprotein retains a prefusion architecture after trypsin cleavage into the S1 and S2 subunits and acidic pH treatment, however, binding to the receptor opens up the receptor-binding domain of S1, which could promote the release of the S 1-ACE2 complex and S1 monomers from the prefusion spike and trigger the pre- to postfusion conformational transition.
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Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
TL;DR: This phenomenon could be extended to other betacoronaviruses utilizing CTD1 of the S1 subunit for receptor binding, which provides new insights into the intermediate states of coronavirus pre-fusion spike trimer during infection.
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Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry
TL;DR: Using surface plasmon resonance (SPR) binding analysis and pseudovirus infection assay, it was shown that several residues in hDPP4–RBD binding interface were important on hDPp4– RBD binding and viral entry.
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Synthesis, characterization, crystal structure, and DFT study of 3,4-Diphenyl -1H-pyrrolo[2,3-b]pyridine
TL;DR: In this paper , 3,4-Diphenyl-1H-pyrrolo[2,3-b]pyridine, a useful organic building block, was obtained via a four-step reaction and the structure was determined using FT-IR, 1H NMR, 13C NMR and mass spectrometry, and the single crystals were characterized using X-ray diffraction analysis.