Miao Gui

TL;DR: Structural comparisons suggested that the SARS-CoV S glycoprotein retains a prefusion architecture after trypsin cleavage into the S1 and S2 subunits and acidic pH treatment, however, binding to the receptor opens up the receptor-binding domain of S1, which could promote the release of the S 1-ACE2 complex and S1 monomers from the prefusion spike and trigger the pre- to postfusion conformational transition.

TL;DR: This phenomenon could be extended to other betacoronaviruses utilizing CTD1 of the S1 subunit for receptor binding, which provides new insights into the intermediate states of coronavirus pre-fusion spike trimer during infection.

TL;DR: Two human monoclonal antibodies, mAb100 and mAb114, in combination, protect nonhuman primates against all signs of Ebola virus disease, including viremia, and the basis of neutralization for two protective antibodies is defined and may facilitate development of therapies and vaccines.

TL;DR: Negative staining images of the intact MHV particles showed that most viral particles had a round shape while some distorted particles were also observed, and it was found that the isolated intact and degraded RNPs are in either relaxed helical sausage-like or supercoiled flower-like structures.

TL;DR: Cryo-EM structures of radial spokes and nexin−dynein regulatory complex attached to doublet microtubules isolated from Chlamydomonas reinhardtii provide a model for mechanoregulation of motile cilia.