W
Weng Naidong
Researcher at Covance
Publications - 47
Citations - 2518
Weng Naidong is an academic researcher from Covance. The author has contributed to research in topics: Liquid chromatography–mass spectrometry & High-performance liquid chromatography. The author has an hindex of 30, co-authored 47 publications receiving 2474 citations.
Papers
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Journal ArticleDOI
Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases.
TL;DR: This review article summarizes the recent progress on bioanalytical LC-MS/MS methods using underivatized silica columns and aqueous/organic mobile phases and proves the silica column demonstrated superior column stability.
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Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography–electrospray tandem mass spectrometric (HILIC–ESI/MS/MS) bioanalysis of basic compounds
Wilson Z. Shou,Weng Naidong +1 more
TL;DR: A simple yet very effective means of minimizing the negative effect of TFA in bioanalysis by direct addition of 0.5% acetic acid or 1% propionic acid to mobile phases containing either 0.025 or 0.05% TFA is presented.
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Novel liquid chromatographic–tandem mass spectrometric methods using silica columns and aqueous–organic mobile phases for quantitative analysis of polar ionic analytes in biological fluids
TL;DR: Use of silica stationary phase and aqueous-organic mobile phases could significantly enhance LC-MS-MS method sensitivity and up to a 20-fold sensitivity increase was observed for acidic polar ionic compounds.
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Simultaneous assay of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma using normal-phase liquid chromatography-tandem mass spectrometry with a silica column and an aqueous organic mobile phase
TL;DR: Method ruggedness was demonstrated by the reproducible performance from multiple analysts using several LC-MS-MS systems to analyze over one thousand samples from clinical trials and Analyte stability during sample processing and storage were established.
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Critical Review of Development, Validation, and Transfer for High Throughput Bioanalytical LC-MS/MS Methods
TL;DR: Strategic approaches for developing and validating robust high throughput LC-MS/MS methods, including automated sample preparation, fast chromatography, minimization of matrix effects, and strategy of narrowing the gap between validation and incurred sample analysis are covered in this review.