Wenly Ruan

TL;DR: The identification of a human-derived microbe, Bifidobacterium dentium, which adheres to intestinal mucus and secretes metabolites that upregulate the major mucin MUC2 and modulate goblet cell function points to the potential of using B. dentium and similar mucin-friendly microbes as therapeutic agents for intestinal disorders with disruptions in the mucus barrier.

TL;DR: The composition and function of the healthy human GI microbiome is reviewed, including the relative abundances of different bacterial taxa and the specific metabolic pathways and classes of microbial metabolites contributing to human health and disease prevention.

TL;DR: Using mice harboring a human microbiome, it is demonstrated that F. nucleatum can promote inflammation, an effect which required antibiotic-mediated alterations in the gut microbiome, suggesting that an intact microbiome is protective against F.ucleatum-mediated immune responses.

TL;DR: The multi‐institutional experience suggests the prognoses of pediatric transplant recipients infected with COVID‐19 may mirror those of immunocompetent children, with infrequent hospitalization and minimal treatment, if any, required.

TL;DR: A unique interaction of between pathogenic C. difficile and F. nucleatum in the intestinal mucus layer is demonstrated and revealed a unique biofilm profile with substantial co-colonization with Fusobacterium.