Wenrong Zhou

TL;DR: It is detected that miR‐140 was uniquely expressed in chondrocyte and suppressed by Wnt/β‐catenin signalling, and Sp1, the activator of the cell cycle regulator p15INK4b, was identified as a target of miR•140 in maintaining the chondrogenic proliferation.

TL;DR: Foxp1/2/4 proteins are established as coordinators of osteogenesis and chondrocyte hypertrophy in developing long bones and it is suggested that a novel transcriptional repressor network involving Foxp1-2-4 may regulate Runx2 during endochondral ossification.

TL;DR: It is demonstrated that Ndrg2, a tumor suppressor gene, was dynamically expressed in the presomitic mesoderm (PSM) and at early stage of differentiating somites and revealed that NDRg2 modulates vertebral identity in segmented somites rather than in the PSM.

TL;DR: Results indicated that PKnox2 misexpression affected mesenchymal condensation and early chondrogenic differentiation in the zeugopod skeletons of transgenic embryos, suggesting Pknox2 as a potential regulator of zeugobod and deltoid crest formation.

TL;DR: In this article , a two-step approach was taken to uncover tumor suppressor gene loss driving immune evasion as step one, and immune sensitizers specifically reversing the immune evasion driven by certain tumor suppressionor loss as step two.