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TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.

TL;DR: The mutation Spike D614G is of urgent concern; it began spreading in Europe in early February, and when introduced to new regions it rapidly becomes the dominant form, indicative of multiple strain infections.

TL;DR: In this paper, the same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2, and the authors review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.

TL;DR: Vital for its success, the database staff are heavy users of the system, which enables them to fix bugs and find opportunities for improvement.

TL;DR: The main features of updated database are described and some basic analyses summarizing evolutionary patterns as they relate to geo-temporal data captured in the database are provided to highlight the most conserved regions in the proteome that may be useful for a T cell vaccine strategy.