Showing papers by "William A. Blattner published in 1982"
TL;DR: The finding of HTLV antibodies in some of the normal population in the Caribbean and Japan, and the clustering of a specific form of T‐cell leukemia/lymphoma in these virus‐endemic areas, suggest that HTLV infection may be associated with the occurrence of a distinctive clinico‐pathologic entity.
Abstract: Type-C RNA tumor viruses have been implicated in the etiology of naturally occurring leukemias and lymphomas of animals. Human T-cell leukemia/lymphoma virus (HTLV) is the first human virus of this class consistently identified in association with a specific type of human leukemia/lymphoma. The isolation of HTLV was made possible by the ability to grow mature T-cells in tissue culture usually with T-cell growth factor (TCGF). We now report a cluster of adult T-cell leukemia/lymphoma among Blacks from the Caribbean in which all eight cases are positive for HTLV virus and/or antibody. These patients have disease that appears indistinguishable from Japanese adult T-cell leukemia/lymphoma which, as we have also reported, is associated with HTLV in over 90% of cases. The finding of HTLV antibodies in some of the normal population in the Caribbean and Japan, and the clustering of a specific form of T-cell leukemia/lymphoma in these virus-endemic areas, suggest that HTLV infection may be associated with the occurrence of a distinctive clinico-pathologic entity.
546 citations
TL;DR: Geographical clustering among certain racial groups suggests common aetiological factors in the pathogenesis of this disease and the finding of high titre antibody against the structural core protein of a new human C-type leukaemia virus in all tested cases from this series and data from all but one case from Japan suggest that one such factor may be viral.
482 citations
16 citations
TL;DR: T-antigen expression in 24 of 31 skin fibroblast cell lines from members of Family G was found to be significantly elevated compared with a healthy control population, however, the pattern of elevation did not appear to be associated with cancer risk.
Abstract: T-antigen expression in 24 of 31 skin fibroblast cell lines from members of Family G was found to be significantly elevated compared with a healthy control population However, the pattern of elevation did not appear to be associated with cancer risk In addition, T-antigen values were independent of the age and sex, as well as the branch of family and generation of the cell donor Cell lines from Family G tended to divide more frequently than cell lines from control donors This tendency was negatively associated with elevated T-antigen expression in Family-G cell lines, while control cell lines showed no such correlation These results demonstrate that caution must be taken in evaluating potential markers of cancer risk Superficial analysis of the data would indicate the utility of the T-antigen assay as a marker for cancer family syndrome However, consideration of additional factors, including pedigree relationships and cell biology in vitro, indicate that SV40 T-antigen expression is an ambiguous marker of this type of cancer risk, even when large groups are studied
2 citations