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William A. Boisvert
Researcher at University of Hawaii at Manoa
Publications - 91
Citations - 6901
William A. Boisvert is an academic researcher from University of Hawaii at Manoa. The author has contributed to research in topics: Inflammation & Macrophage. The author has an hindex of 36, co-authored 91 publications receiving 6365 citations. Previous affiliations of William A. Boisvert include University of Oregon & Tufts University.
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Journal ArticleDOI
A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
Ajay Chawla,William A. Boisvert,Chih-Hao Lee,Bryan A. Laffitte,Yaacov Barak,Sean B. Joseph,Debbie Liao,Laszlo Nagy,Peter A. Edwards,Linda K. Curtiss,Ronald M. Evans,Peter Tontonoz +11 more
TL;DR: It is proposed that PPARγ coordinates a complex physiologic response to oxLDL that involves particle uptake, processing, and cholesterol removal through ABCA1.
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Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ
TL;DR: An unconventional ligand-dependent transcriptional pathway is proposed in which PPARδ controls an inflammatory switch through its association and disassociation with transcriptional repressors and may thus serve as therapeutic targets to attenuate inflammation and slow the progression of atherosclerosis.
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A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
TL;DR: The capacity of leukocytes to express mIL-8RH, and associated intralesional expression of its ligands such as KC/GROalpha, mediated the intimal accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
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Overexpression of Interleukin-10 by Activated T Lymphocytes Inhibits Atherosclerosis in LDL Receptor–Deficient Mice by Altering Lymphocyte and Macrophage Phenotypes
Laura J. Pinderski,Michael P. Fischbein,Ganesamoorthy Subbanagounder,Michael C. Fishbein,Nobuhiko Kubo,Hilde Cheroutre,Linda K. Curtiss,Judith A. Berliner,William A. Boisvert +8 more
TL;DR: It is demonstrated that T lymphocyte IL-10 can influence the function of other immune cells to reduce the development of advanced atherosclerotic lesions in mice.
Journal ArticleDOI
Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia
Rafal Pawlinski,Brian Pedersen,Gernot Schabbauer,Michael Tencati,Todd Holscher,William A. Boisvert,Patricia Andrade-Gordon,Rolf Dario Frank,Nigel Mackman +8 more
TL;DR: Data demonstrate that hematopoietic cells are the major pathologic site of TF expression during endotoxemia and suggest that multiple protease-activated receptors mediate crosstalk between coagulation and inflammation.