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William A. Pulsinelli
Researcher at Cornell University
Publications - 60
Citations - 9490
William A. Pulsinelli is an academic researcher from Cornell University. The author has contributed to research in topics: Ischemia & Hippocampus. The author has an hindex of 40, co-authored 60 publications receiving 9356 citations. Previous affiliations of William A. Pulsinelli include University of Tennessee Health Science Center.
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Delayed hippocampal damage in humans following cardiorespiratory arrest
TL;DR: Brain slides from all patients with anoxic-ischemic encephalopathy and a well-documented cardiorespiratory arrest were reexamined, finding delayed hippocampal injury now documented in humans provides a target for possible therapy that can be initiated after cardiopulmonary resuscitation.
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Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications.
TL;DR: It is shown that ischemic injury to neurons in rat brain is also potentiated by exposure to high physiological titers of glucocorticoids and is attenuated by adrenalectomy.
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Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia
TL;DR: The neuroprotective activity of MK-801 against transient global ischemia appears to be largely a consequence of postischemic hypothermia rather than a direct action on NMDA receptor-channels.
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Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia.
TL;DR: Progressive brain damage after transient cerebral ischemia may be related to changes in postischemic cerebral blood flow and metabolism and ways to manipulate CBF and metabolism in the treatment of stroke are defined.
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Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model:
TL;DR: It is concluded that LDF does not provide accurate measurements of absolute rCBF values but this method allows accurately measurements of changes in r CBF due to induction of focal cerebral ischemia.