William C. Dewey

TL;DR: The equations and methods described in this report are intended to provide a simple but effective means for thermal dose estimation for clinical use and to stimulate efforts to evaluate data in terms of therapeutically useful thermal units.

TL;DR: It is demonstrated that brief inactivation of MYC results in the sustained regression of tumors and the differentiation of osteogenic sarcoma cells into mature osteocytes, raising the possibility that transient in activation ofMYC may be an effective therapy for certain cancers.

TL;DR: Data are shown which indicate that in order to test for thermal tolerance in the clinic and to have a successful phase III trial, the thermal dose should be increased about five-fold compared with what has been achieved in previous clinical trials.

TL;DR: Molecular events that determine whether a cell that divides with or without a chromosomal aberration will produce progeny that apoptose or necrose need to be identified are important for determining how modulation of radiation-induced apoptosis will affect the ultimate clonogenic survival, and possibly genomic instability in the surviving progeny.

TL;DR: The survival of Chinese hamster ovary cells exposed to hyperthermic temperatures of 42.5–46.0° decreases exponentially as a function of duration of heat exposure in a manner quite similar to survival as a functions of radiation dose.