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William C. Smith
Researcher at University of California, Santa Barbara
Publications - 75
Citations - 5766
William C. Smith is an academic researcher from University of California, Santa Barbara. The author has contributed to research in topics: Ciona & Ciona intestinalis. The author has an hindex of 31, co-authored 73 publications receiving 5579 citations. Previous affiliations of William C. Smith include University of California, Berkeley & University of Oxford.
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Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
TL;DR: The activity of exogenous noggin RNA in embryonic axis induction and the localized expression of endogenous noggan transcripts suggest that noggins plays a role in normal dorsal development.
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Neural induction by the secreted polypeptide noggin
Teresa M. Lamb,Anne K. Knecht,William C. Smith,Scott E. Stachel,Aris N. Economides,Neil Stahl,George D. Yancopolous,Richard M. Harland +7 more
TL;DR: Noggin has the expression pattern and activity expected of an endogenous neural inducer and acts at the appropriate stage to be an endogenous Neural inducing signal in Xenopus.
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Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center.
TL;DR: Xwnt-8, which is normally expressed ventrally in midgastrula and neurula embryos, appears to mimic, when injected, maternally encoded dorsal mesoderm-inducing factors that act early in development.
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Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm
TL;DR: It is shown that soluble noggin protein added to ventral marginal zones during gastrulation induces muscle, but that activin does not, and the results suggest that the noggins product may be the dorsalizing signal from the organizer.
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A nodal-related gene defines a physical and functional domain within the Spemann organizer.
TL;DR: A functional screen for gene products that rescue dorsal development in ventralized Xenopus embryos has yielded Xenopus nodal-related 3 (Xnr3), a diverged member of the TGF beta superfamily, consistent with a role in patterning the gastrula.