Showing papers by "William E. Boden published in 2012"
Emory University1, Christiana Care Health System2, Vanderbilt University Medical Center3, Cleveland Clinic4, Cedars-Sinai Medical Center5, Hartford Hospital6, Vancouver Hospital and Health Sciences Centre7, University of Missouri–Kansas City8, London Health Sciences Centre9, Montreal Heart Institute10, Saint Louis University11, University of Michigan12, McMaster University13, University at Buffalo14
TL;DR: From the COURAGE trial post hoc substudy, the extent of site-defined ischemia did not predict adverse events and did not alter treatment effectiveness.
164 citations
TL;DR: The decision of when dual antiplatelet therapy can be safely interrupted needs to be individualized for each patient and involves factoring in the type of stent; the location and complexity of the lesion stented; post-stent lesion characteristics; the amount of time since stent placement; and theAntiplatelet regimen currently in use, along with its implication for bleeding during the proposed procedure.
Abstract: Coronary artery disease is the primary cause of mortality in men and women in the United States. Transcatheter coronary intervention is the mainstay of treatment for patients with acute coronary artery disease presentations and patients with stable disease. Although percutaneous intervention initially only included balloon angioplasty, it now typically involves the placement of intracoronary stents. To overcome the limitations of bare-metal stents, namely in-stent restenosis, stents have been developed that remove pharmaceuticals that reduce neointimal hyperplasia and in-stent restenosis. However, these pharmaceutical agents also delay stent endothelialization, posing a prolonged risk of in situ thrombosis. Placement of an intracoronary stent (eg, bare-metal or drug-eluting stent) requires dual antiplatelet therapy to prevent the potentially life-threatening complication of stent thrombosis. The optimal duration of dual antiplatelet therapy following stent placement is unknown. This article discus...
1 citations