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William Farrell
Researcher at Pfizer
Publications - 25
Citations - 1257
William Farrell is an academic researcher from Pfizer. The author has contributed to research in topics: Supercritical fluid chromatography & Hydrophilic interaction chromatography. The author has an hindex of 16, co-authored 25 publications receiving 923 citations.
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Journal ArticleDOI
A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow.
Damith Perera,Joseph W. Tucker,Shalini Brahmbhatt,Christopher John Helal,Ashley Chong,William Farrell,Paul G. Richardson,Neal W. Sach +7 more
TL;DR: An automated flow-based synthesis platform that integrates both rapid nanomoles-scale reaction screening and micromole-scale synthesis into a single modular unit is reported here.
Journal ArticleDOI
Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity
Justin M. Lopchuk,Kasper Fjelbye,Yu Kawamata,Lara R. Malins,Chung-Mao Pan,Ryan Gianatassio,Jie Wang,Liher Prieto,James Bradow,Thomas Andrew Brandt,Michael R. Collins,Jeff Elleraas,Jason Ewanicki,William Farrell,Olugbeminiyi O. Fadeyi,Gary M. Gallego,James J. Mousseau,Robert M. Oliver,Neal W. Sach,Jason K. Smith,Jillian E. Spangler,Huichin Zhu,Jinjiang Zhu,Phil S. Baran +23 more
TL;DR: The development, synthesis, scope of reaction, bioconjugation, and synthetic comparisons of four new chiral “cyclopentylation” reagents of amines, alcohols, thiols, carboxylic acids, and other heteroatoms is introduced.
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Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA
Jie Wang,Helena Lundberg,Shota Asai,Pedro Martín-Acosta,Jason S. Chen,Stephen P. Brown,William Farrell,Russell Dushin,Christopher J. O’Donnell,Anokha S. Ratnayake,Paul G. Richardson,Zhiqing Liu,Tian Qin,Donna G. Blackmond,Phil S. Baran +14 more
TL;DR: A systematic approach to translating standard organic reactions to a DEL setting through the tactical combination of kinetic analysis and empirical screening with information captured from data mining is described.
Journal ArticleDOI
SFC/MS in drug discovery at Pfizer, La Jolla
Ben Bolaños,Michael J. Greig,Manuel Ventura,William Farrell,Christine Aurigemma,Haitao Li,Terri Quenzer,Kathleen Tivel,Jessica M. R. Bylund,Phuong Tran,Catherine Pham,Doug Phillipson +11 more
TL;DR: The use of supercritical fluid chromatography/mass spectrometry for numerous applications in drug discovery at Pfizer, La Jolla has been heavily relied upon for analysis and purification of a diverse set of compounds from the in-house chemical library.
Journal ArticleDOI
High Throughput Method for the Indirect Detection of Intramolecular Hydrogen Bonding
Gilles H. Goetz,William Farrell,Marina Shalaeva,Simone Sciabola,Dennis P. Anderson,Jiangli Yan,Laurence Philippe,Michael J. Shapiro +7 more
TL;DR: A supercritical fluid chromatography method was developed for the detection of intramolecular hydrogen bonds in pharmaceutically relevant molecules and correlates chromatographic retention with the exposed polarity of a molecule.