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William H. Wunner
Researcher at Wistar Institute
Publications - 71
Citations - 5135
William H. Wunner is an academic researcher from Wistar Institute. The author has contributed to research in topics: Rabies virus & Virus. The author has an hindex of 35, co-authored 71 publications receiving 5028 citations. Previous affiliations of William H. Wunner include Thomas Jefferson University & University of Pennsylvania.
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Journal ArticleDOI
Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus
Bernhard Dietzschold,William H. Wunner,Tadeusz J. Wiktor,A D Lopes,M. Lafon,C L Smith,Hilary Koprowski +6 more
TL;DR: It is concluded that arginine-333 is essential for the integrity of an antigenic determinant and for the ability of rabies viruses to produce lethal infection in adult mice.
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Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus.
Zhi Quan Xiang,Steven L. Spitalnik,Minh Tran,William H. Wunner,Jun Cheng,Hildegund C.J. Ertl +5 more
TL;DR: A plasmid vector, termed pSG5rab.gp, that expresses the rabies virus glycoprotein under the control of an SV40 early promoter, was tested in C3H/He mice for induction of rabie virus-specific immune responses and was fully protected against a subsequent challenge with rabiesirus.
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Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene
Tadeusz J. Wiktor,R I Macfarlan,K J Reagan,Bernhard Dietzschold,P J Curtis,William H. Wunner,Marie-Paule Kieny,Richard Lathe,J P Lecocq,M Mackett +9 more
TL;DR: V-RGpro8 virus was highly effective in priming mice to generate a secondary rabies virus-specific cytotoxic T-lymphocyte response following culture of lymphocytes with either ERA or PM strains of rabiesirus.
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Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.
Charles E. Rupprecht,Tadeusz J. Wiktor,David H. Johnston,Amir N. Hamir,Bernhard Dietzschold,William H. Wunner,Lawrence T. Glickman,Hilary Koprowski +7 more
TL;DR: This work demonstrates the feasibility of a recombinant virus vaccine containing the rabies glycoprotein gene for immunization of raccoons, and possibly other wildlife, to obtain long-term protection against rabies.
Journal ArticleDOI
Management of Rabies in Humans
Alan Jackson,M. J. Warrell,Charles E. Rupprecht,Hildegund C. J. Ertl,Bernhard Dietzschold,Michael O'Reilly,Richard P. Leach,Zhen F. Fu,William H. Wunner,Thomas P. Bleck,Henry Wilde +10 more
TL;DR: No single therapeutic agent is likely to be effective, but a combination of specific therapies could be considered, including rabies vaccine, rabies immunoglobulin, monoclonal antibodies, ribavirin, interferon-alpha, and ketamine.