William J. Shufesky

TL;DR: It is demonstrated that DCs release exosomes with different miRNAs depending on the maturation of the DCs, and exosome-shuttle miRNAAs are functional, because they repress target mRNAs of acceptor DCs.

TL;DR: It is demonstrated that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells, implying that exOSomes present in circulation or extracellular fluids constitute an alternative source of self- or allopeptides for DCs during maintenance of peripheral tolerance or initiation of the indirect pathway of allorecognition in transplantation.

TL;DR: Characterization of apoptotic cell/DC interaction and its outcome provides insight into the mechanisms by which apoptotic cells affect DC function without disrupting peripheral tolerance.

TL;DR: The results suggest that exchange of exosomes between DCs in lymphoid organs might constitute a potential mechanism by which passenger leukocytes transfer alloantigens to recipient’s APCs and amplify generation of donor-reactive T cells following transplantation.

TL;DR: A key role is supported for transfer of donor EVs in the generation of allograft-targeting immune responses and it is suggested that interrupting this process has potential to dampen the immune response to allografteds.