J
James Lyons-Weiler
Researcher at University of Pittsburgh
Publications - 67
Citations - 3980
James Lyons-Weiler is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Phylogenetic tree & Gene. The author has an hindex of 29, co-authored 67 publications receiving 3606 citations. Previous affiliations of James Lyons-Weiler include University of Nevada, Reno & Pennsylvania State University.
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Journal ArticleDOI
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
Angela Montecalvo,Adriana T. Larregina,William J. Shufesky,Donna B. Stolz,Mara Sullivan,Jenny Karlsson,Catherine J. Baty,Gregory A. Gibson,Geza Erdos,Zhiliang Wang,Jadranka Milosevic,Olga A. Tkacheva,Sherrie J. Divito,Rick Jordan,James Lyons-Weiler,Simon C. Watkins,Adrian E. Morelli +16 more
TL;DR: It is demonstrated that DCs release exosomes with different miRNAs depending on the maturation of the DCs, and exosome-shuttle miRNAAs are functional, because they repress target mRNAs of acceptor DCs.
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Altered global gene expression in first trimester placentas of women destined to develop preeclampsia.
Sandra A. Founds,Yvette P. Conley,James Lyons-Weiler,Arun Jeyabalan,W. Allen Hogge,Kirk P. Conrad +5 more
TL;DR: This is the first study to show dysregulation of gene expression in the early placentas of women approximately 6 months before developing preeclampsia, thereby reinforcing a placental origin of the disorder.
Journal ArticleDOI
Microbial Risk Indicators of Early Childhood Caries
Patricia Corby,Patricia Corby,Patricia Corby,James Lyons-Weiler,Walter A. Bretz,Thomas C. Hart,Jørn A. Aas,Tahani Boumenna,John A. Goss,Andrea L. Corby,H. M. Junior,Robert J. Weyant,Bruce J. Paster +12 more
TL;DR: Molecular identification methods, such as 16S RNA gene sequence and reverse-capture checkerboard hybridization, are used for identification of the bacteria associated with dental caries and with dental health in a subset of 204 twins, suggesting that global patterns of microbial abundance in this population are very distinctive.
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Independent and combined analyses of sequences from all three genomic compartments converge on the root of flowering plant phylogeny
Todd J. Barkman,Gordon Chenery,Joel R. McNeal,James Lyons-Weiler,Wayne J. Ellisens,Gerry Moore,Andrea D. Wolfe,Claude W. dePamphilis +7 more
TL;DR: Results are presented from separate and combined genomic analyses of new and previously published data, including six and nine genes for different subsets of taxa that suggest Amborella + Nymphaeales (water lilies) are the first-branching angiosperm lineage.
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Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension.
Eileen Hsu,Haiwen Shi,Rick Jordan,James Lyons-Weiler,Joseph M. Pilewski,Carol Feghali-Bostwick +5 more
TL;DR: Using microarray analysis on carefully phenotyped SSc and comparator lung tissues, distinct molecular profiles in tissues and fibroblasts from patients with SSc-associated lung disease compared to idiopathic forms of lung disease are demonstrated.