Adriana T. Larregina

TL;DR: It is demonstrated that DCs release exosomes with different miRNAs depending on the maturation of the DCs, and exosome-shuttle miRNAAs are functional, because they repress target mRNAs of acceptor DCs.

TL;DR: It is demonstrated that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells, implying that exOSomes present in circulation or extracellular fluids constitute an alternative source of self- or allopeptides for DCs during maintenance of peripheral tolerance or initiation of the indirect pathway of allorecognition in transplantation.

TL;DR: Characterization of apoptotic cell/DC interaction and its outcome provides insight into the mechanisms by which apoptotic cells affect DC function without disrupting peripheral tolerance.

TL;DR: It is demonstrated that, depending on the stimuli used to terminally mature BM DCs, DCs synthesize a different pattern of cytokines and exhibit distinct Th cell-driving potential.

TL;DR: It is shown that, as a result of rAd infection, mouse bone marrow-derived immature DC upregulate expression of major histocompatibility complex class I and II antigens, costimulatory molecules (CD40, CD80, and CD86), and the adhesion molecule CD54 (ICAM-1).