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William J. Swiggard
Researcher at Rockefeller University
Publications - 21
Citations - 4612
William J. Swiggard is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antigen & Virus. The author has an hindex of 18, co-authored 21 publications receiving 4486 citations. Previous affiliations of William J. Swiggard include University of Pennsylvania & Northampton Community College.
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Journal ArticleDOI
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
Wanping Jiang,William J. Swiggard,Christine Heufler,Christine Heufler,Michael Peng,Asra Mirza,Ralph M. Steinman,Michel C. Nussenzweig,Michel C. Nussenzweig +8 more
TL;DR: DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.
Journal Article
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.
Una O'Doherty,M Peng,Stuart Gezelter,William J. Swiggard,Michiel G. H. Betjes,Nina Bhardwaj,Ralph M. Steinman +6 more
TL;DR: It is hypothesized that the CD11c-negative immature cells are marrow-derived precursors to tissue dendritic cells, such as epidermal Langerhans' cells, while the CD 11c-positive cells are derived from tissues where they have been activated by antigen, and are en route to the spleen or lymph nodes to stimulate T-cell responses there.
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Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding
TL;DR: It is proposed that spinoculation works by depositing virions on the surfaces of target cells and that diffusion is the major rate-limiting step for viral adsorption under routine in vitro pulsing conditions.
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An iron-carboxylate bond links the heme units of malaria pigment
Andrew F. G. Slater,William J. Swiggard,Brian R. Orton,William D. Flitter,Daniel E. Goldberg,Anthony Cerami,Graeme B. Henderson +6 more
TL;DR: Hemozoin is purified from the human malaria organism Plasmodium falciparum and has been used to determine its structure, which consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another.
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Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes.
Kayo Inaba,William J. Swiggard,Muneo Inaba,Joseph Meltzer,Asra Miryza,Tatsuya Sasagawa,Michel C. Nussenzweig,Ralph U. Steinman +7 more
TL;DR: DEC-205 is therefore more broadly expressed on leukocytes than previously appreciated, but its function remains unclear.