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William N. Frost
Researcher at Rosalind Franklin University of Medicine and Science
Publications - 48
Citations - 2117
William N. Frost is an academic researcher from Rosalind Franklin University of Medicine and Science. The author has contributed to research in topics: Central pattern generator & Interneuron. The author has an hindex of 22, co-authored 47 publications receiving 2006 citations. Previous affiliations of William N. Frost include University of Texas Health Science Center at Houston & University of Texas at Austin.
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Journal ArticleDOI
Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization.
TL;DR: It is found that in the gill- and siphon- withdrawal reflex of Aplysia, the memory for short-term sensitization grades smoothly into long-term memory with increased amounts of sensitization training, and this finding should facilitate study of the cellular and molecular mechanisms involved in the conversion of short- term to long- term memory.
Journal ArticleDOI
Intrinsic neuromodulation: altering neuronal circuits from within
Paul S. Katz,William N. Frost +1 more
TL;DR: There are two sources of neuromodulation for neuronal circuits: extrinsic inputs and intrinsic components of the circuits themselves, which produce local changes in neuronal computation and can cause global changes, often affecting many circuits simultaneously.
Journal ArticleDOI
Dynamic neuromodulation of synaptic strength intrinsic to a central pattern generator circuit
TL;DR: Results indicate that during the escape swim, circuit connection strengths are dynamically controlled by the activity of neurons within the circuit itself, which may be important for the animal's initial decision to swim, the generation of the swim motor programme itself, and certain types of learning.
Journal ArticleDOI
Parallel processing of short-term memory for sensitization in Aplysia.
TL;DR: The short-term memory for sensitization is examined, using the siphon component of the defensive gill- and siphon-withdrawal reflex, and is found to be represented by at least four sites of circuit modification, each involving a different type of plasticity.
Journal ArticleDOI
Single neuron control over a complex motor program
William N. Frost,Paul S. Katz +1 more
TL;DR: A single interneuron, DRI, is identified that elicits the swim motor program when driven with intracellular stimulation, and blocks the depolarizing "ramp" input to the central pattern generator, and consequently the motor program itself, when hyperpolarized during the nerve stimulus.