R
Robert D. Hawkins
Researcher at Columbia University
Publications - 99
Citations - 12368
Robert D. Hawkins is an academic researcher from Columbia University. The author has contributed to research in topics: Long-term potentiation & Postsynaptic potential. The author has an hindex of 52, co-authored 97 publications receiving 11970 citations. Previous affiliations of Robert D. Hawkins include University of York.
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Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
TL;DR: Two major membrane-permeant candidate retrograde messengers are investigated, arachidonic acid and nitric oxide, and no enhances spontaneous presynaptic release of transmitter from hippocampal neurons in dissociated cell culture, suggesting that NO might be a retrograde messenger in LTP.
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A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.
TL;DR: Results of these cellular experiments are quantitatively similar to the results of behavioral experiments with the same protocol and parameters, suggesting that activity-dependent amplification of presynaptic facilitation may make a significant contribution to classical conditioning of the withdrawal reflex.
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Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus
TL;DR: Results are consistent with the hypothesis that NO and CO, either alone or in combination, serve as retrograde messages that produce activity-dependent presynaptic enhancement during LTP.
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Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.
Mary Elizabeth Bach,Mark Barad,Hyeon Son,Min Zhuo,Yun Fei Lu,Robert M. Shih,Isabelle M. Mansuy,Robert D. Hawkins,Eric R. Kandel +8 more
TL;DR: Both dopamine D1/D5 receptor agonists, which are positively coupled to adenylyl cyclase, and a cAMP phosphodiesterase inhibitor ameliorated the physiological as well as the memory defects, consistent with the idea that the cAMP-protein kinase A-dependent signaling pathway is defective in age-related spatial memory loss.
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Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade
Clifford Kentros,Eric L. Hargreaves,Robert D. Hawkins,Eric R. Kandel,Matthew D. Shapiro,Robert Müller +5 more
TL;DR: In this paper, an acute pharmacological blockade of N-methyl-D-aspartate (NMDA) glutamate receptors was used to investigate how NMDA-based synaptic plasticity participates in the formation and maintenance of the firing fields.