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William P. Coleman
Researcher at Rush University
Publications - 15
Citations - 3095
William P. Coleman is an academic researcher from Rush University. The author has contributed to research in topics: Spinal cord injury & Randomized controlled trial. The author has an hindex of 12, co-authored 15 publications receiving 2861 citations.
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Journal ArticleDOI
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials
James W. Fawcett,Armin Curt,John D. Steeves,William P. Coleman,Mark H. Tuszynski,Daniel P. Lammertse,Perry F. Bartlett,Andrew R. Blight,Volker Dietz,John F. Ditunno,Bruce H. Dobkin,Leif A. Havton,P H Ellaway,Michael G. Fehlings,A Privat,Robert G. Grossman,James D. Guest,Naomi Kleitman,Masaya Nakamura,M. Gaviria,D J Short +20 more
TL;DR: The spontaneous rate of recovery after SCI and resulting consequences for achieving statistically significant results in clinical trials are examined, based on previous data of the magnitude of spontaneous recovery afterSCI, as measured by changes in ASIA motor scores.
Journal ArticleDOI
Recovery of Motor Function after Spinal-Cord Injury — A Randomized, Placebo-Controlled Trial with GM-1 Ganglioside
TL;DR: Evidence is provided that GM-1 enhances the recovery of neurologic function after one year in patients with spinal-cord injuries and that the increased recovery was attributable to initially paralyzed muscles that regained useful motor strength rather than to strengthening of paretic muscles.
Journal ArticleDOI
Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures
John D. Steeves,Daniel P. Lammertse,Armin Curt,James W. Fawcett,Mark H. Tuszynski,John F. Ditunno,P H Ellaway,Michael G. Fehlings,James D. Guest,Naomi Kleitman,Perry F. Bartlett,Andrew R. Blight,Volker Dietz,Bruce H. Dobkin,Robert G. Grossman,D J Short,Masaya Nakamura,William P. Coleman,M. Gaviria,A Privat +19 more
TL;DR: An international panel reviewed the methodology for clinical trials of spinal cord injury (SCI), and provided recommendations for the valid conduct of future trials, and focused on outcome measures that are relevant toclinical trials of experimental cell-based and pharmaceutical drug treatments.
Journal ArticleDOI
The Sygen® multicenter acute Spinal cord injury study
TL;DR: Although not proven in the primary efficacy analysis of this trial, Sygen® appears to be beneficial in patients with severe spinal cord injury.
Journal ArticleDOI
A critical appraisal of the reporting of the National Acute Spinal Cord Injury Studies (II and III) of methylprednisolone in acute spinal cord injury.
William P. Coleman,Edward C. Benzel,David W. Cahill,Thomas B. Ducker,Fred H. Geisler,Barth A. Green,Mitchell R. Gropper,Jan Goffin,Parley W. Madsen,Dennis J. Maiman,Stephen L. Ondra,Michael K. Rosner,Rick C. Sasso,Gregory R. Trost,Seth M. Zeidman +14 more
TL;DR: The NASCIS group's decision to admit persons with minor SCIs with minimal or no motor deficit not only enables statistical artifacts it complicates the interpretation of results from the population actually sampled, and the results of these studies show statistical artifacts that call their results into question.