W
William R. Hewitt
Researcher at Université de Montréal
Publications - 8
Citations - 294
William R. Hewitt is an academic researcher from Université de Montréal. The author has contributed to research in topics: Nephrotoxicity & Toxicity. The author has an hindex of 8, co-authored 8 publications receiving 292 citations.
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Acute alteration of chloroform-induced hepato- and nephrotoxicity by n-hexane, methyl n-butyl ketone, and 2,5-hexanedione☆☆☆
TL;DR: The concept that ketones increase the susceptibility of animals to the toxic effects of haloalkanes is supported, as the ability to potentiate CHCl3-induced liver injury increased in the order of H < A < 2,5-HD ≅ MBK.
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Acute alteration of chloroform-induced hepato- and nephrotoxicity by mirex and Kepone
TL;DR: Results indicate that Kepone ingestion may increase the sensitivity of the liver and kidney to CHCl 3 toxicity.
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Role of biotransformation in the alterations of chloroform hepatotoxicity produced by Kepone and mirex.
TL;DR: It appears that the disparate potentiating abilities of mirex and Kepone are related to a difference in the capacity of these agents to increase the activity of the CHCl 3 bioactivation system of the liver.
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Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone.
TL;DR: The ability of acetone to potentiate the toxicity of 1,1-dichloroethylene in male rats was investigated and biphasic potentiation of DCE-induced hepatotoxicity was observed.
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Fractional hepatic localization of 14CHCl3 in mice and rats treated with chlordecone or mirex.
TL;DR: Results suggest that differences exist between chlordecone and mirex with respect to their capacity to increase the quantity of CHCl3-derived reactive metabolite and the eventual distribution of reactive metabolites.