Journal ArticleDOI
Acute alteration of chloroform-induced hepato- and nephrotoxicity by mirex and Kepone
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TLDR
Results indicate that Kepone ingestion may increase the sensitivity of the liver and kidney to CHCl 3 toxicity.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1979-05-01. It has received 67 citations till now. The article focuses on the topics: Kepone & Nephrotoxicity.read more
Citations
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Potentiation of the hepatotoxicity of carbon tetrachloride following preexposure to chlordecone (Kepone) in the male rat
TL;DR: The data indicate a great potential for production of severe liver damage resulting from interactions of CCl4 and CD exposure at levels which may be independently nontoxic.
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Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two-stage model of toxicity.
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Cytochrome P-450-dependent formation of reactive oxygen radicals: isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride.
TL;DR: It is concluded that microsomal oxidase activity takes place at physiological concentrations of O2 and that isozyme-specific type II ligands compete with oxygen or carbon tetrachloride for reduction by P-450 haem.
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ATSDR evaluation of health effects of chemicals. II. Mirex and chlordecone: health effects, toxicokinetics, human exposure, and environmental fate.
TL;DR: This document provides public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of mirex and chlordecone.
References
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Journal ArticleDOI
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
Journal ArticleDOI
The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man.
TL;DR: Substantially substituted derivatives of hippuric acid which could be determined by appropriate coupling reactions were prepared and studied under conditions permitting the exact comparison of renal clearances with those of diodrast atnd hippuran.
Journal Article
Acetaminophen-induced hepatic necrosis. i. role of drug metabolism
TL;DR: It is proposed thatacetaminophen-induced hepatic necrosis is mediated by a toxic metabolite of acetaminophen, which inhibits synthesis of cytochrome P-450 and thereby prevented the hepatic damage.