William T. Shi

TL;DR: Different aspects of subharmonic imaging are reviewed including implementation, in-vitro gray-scale imaging and sub Harmonic aided pressure estimation.

TL;DR: The nonlinear properties of microbubble contrast agents have been used to create contrast-specific imaging modalities such as harmonic imaging and subharmonic imaging and a better understanding of the nonlinear performance of contrast microbubbles may enhance the diagnostic capabilities of medical ultrasound (US) imaging.

TL;DR: The subharmonic emission from insonified contrast microbubbles was used to create a new imaging modality called Subharmonic Imaging and excellent suppression of all backscattered signals other than from contrast micro bubbles was achieved for sub Harmonic A-lines in vitro while further optimization is required for in vivo gray scale subharmonics images.

TL;DR: It is indicated that inertial cavitation is unlikely to take place in the presence of Sonazoid contrast microbubbles when exposed to diagnostic US with an MI <1.0, implying that the destruction at moderate pressures is a relatively slow (relative to inertial bubble collapse), nonviolent dissolution process following the disruption of encapsulating surface materials.

TL;DR: The aortas of two dogs were scanned with an experiment pulse-echo system to validate in vivo pressure estimation based on subharmonic microbubble signals, which matched well with instantaneous pressure measurements obtained simultaneously with a pressure catheter.