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William Wallace
Researcher at Royal Hospital for Sick Children
Publications - 166
Citations - 11429
William Wallace is an academic researcher from Royal Hospital for Sick Children. The author has contributed to research in topics: Fertility preservation & Cancer. The author has an hindex of 50, co-authored 159 publications receiving 10261 citations. Previous affiliations of William Wallace include Air Force Research Laboratory & University of Edinburgh.
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Journal ArticleDOI
Effects of a third intensification block of chemotherapy on bone and collagen turnover, insulin-like growth factor I, its binding proteins and short-term growth in children with acute lymphoblastic leukaemia.
Patricia M. Crofton,Patricia M. Crofton,Syed Faisal Ahmed,Jean Wade,Martin W. Elmlinger,Michael B. Ranke,Christopher J. H. Kelnar,William Wallace +7 more
TL;DR: It is concluded that dexamethasone decreased bone and soft tissue turnover, probably through direct effects on target tissues, in children with ALL randomised to receive an additional third intensification block of chemotherapy.
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Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer.
Melissa D. Tharmalingam,Melissa D. Tharmalingam,Gabriele Matilionyte,William Wallace,Jan-Bernd Stukenborg,Kirsi Jahnukainen,Kirsi Jahnukainen,Elizabeth Oliver,Anne Goriely,Sheila Lane,Jingtao Guo,Bradley R. Cairns,Anne Jørgensen,Caroline M Allen,Federica Lopes,Richard A. Anderson,Norah Spears,Rod T. Mitchell,Rod T. Mitchell +18 more
TL;DR: This is the first demonstration of direct effects of chemotherapy exposure on germ cell populations in human foetal and prepubertal testis, demonstrating platinum-induced loss of all germcell populations, and similar effects of cisplatin or carboplatin.
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Survivors of childhood cancer lost to follow-up can be re-engaged into active long-term follow-up by a postal health questionnaire intervention.
TL;DR: Postal follow-up is an effective means of re-engaging more than one third of survivors of childhood cancer in active long-term follow-ups, half of whom had at least one late effect.
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Fertility preservation for girls and young women with cancer: what are the remaining challenges?
William Wallace,Ronald D. Barr +1 more
TL;DR: The excellent and balanced article by Jadoul et al., in this issue of HRU, reviews the available evidence for fertility preservation in girls and young women at risk of a premature menopause and demonstrates the difficulty of giving an accurate prognosis for fertility before treatment starts.